{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T20:15:33Z","timestamp":1773173733931,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T00:00:00Z","timestamp":1537315200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Juvenile generalized pustular psoriasis (<jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content>) is rare and often resistant to conventional systemic therapy such as methotrexate, retinoic acid and cyclosporin A. <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> can be induced by deficiency of interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201036 receptor antagonist (<jats:styled-content style=\"fixed-case\">DITRA<\/jats:styled-content>). No standardized guidelines are available for juvenile <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">DITRA<\/jats:styled-content>, and a uniformly safe and effective biologic agent has not been identified. However, multiple biologics approved for use in plaque\u2010type psoriasis have also been used in <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content>. Herein, we report a case of a 6\u2010year\u2010old Taiwanese boy with <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> and homozygous mutation at c.115+6T&gt;C within the <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201036 receptor antagonist (<jats:italic><jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>36<jats:styled-content style=\"fixed-case\">RN<\/jats:styled-content><\/jats:italic>) gene, who was treated successfully with secukinumab after failure of prior methotrexate, acitretin, cyclosporin A, etanercept and adalimumab. Similar to two previously reported non\u2010adult cases of <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> successfully treated with secukinumab, our case also demonstrated a history of repeated treatment failures with several conventional oral systemic agents and biologics. Different from these two cases, however, ours is the first of juvenile <jats:styled-content style=\"fixed-case\">GPP<\/jats:styled-content> successfully treated with secukinumab monotherapy, without using other systemic agent concurrently during the use of secukinumab.<\/jats:p>","DOI":"10.1111\/1346-8138.14636","type":"journal-article","created":{"date-parts":[[2018,9,19]],"date-time":"2018-09-19T19:53:48Z","timestamp":1537386828000},"page":"1353-1356","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Successful treatment of refractory juvenile generalized pustular psoriasis with secukinumab monotherapy: A case report and review of published work"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5373-4970","authenticated-orcid":false,"given":"Po\u2010Han","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsen\u2010Fang","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,9,19]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"216","article-title":"An epidemiologic study of Taiwanese psoriatic patients in a single clinic","volume":"21","author":"Chen HH","year":"2003","journal-title":"Dermatol Sinica"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12351"},{"key":"e_1_2_5_4_1","first-page":"e652","article-title":"Biologics and pediatric generalized pustular psoriasis: an emerging therapeutic trend","volume":"8","author":"Saikaly SK","year":"2016","journal-title":"Cureus"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-015-1611-x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13306"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13622"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.14702"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex510"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0372-5"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12710"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-15892-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013068"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.3490"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.876"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301668"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14636","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14636","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T14:56:23Z","timestamp":1694876183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,19]]},"references-count":15,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2018,11]]}},"alternative-id":["10.1111\/1346-8138.14636"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14636","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,19]]},"assertion":[{"value":"2018-05-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}