{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:32:17Z","timestamp":1783758737750,"version":"3.55.0"},"reference-count":13,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mosquito bite reactions consist of an immediate response characterized by an erythema and a wheal, which peaks at 20 min, and a delayed response characterized by a papule and\/or an erythema, which peaks at 24 h. Mosquito bite reactions progress from stage I to stage V as an individual is repeatedly bitten as follows: stage I, neither immediate nor delayed reaction; stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content>, delayed reaction; stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>, both immediate and delayed reaction; stage <jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>, immediate reaction; and stage V, neither immediate nor delayed reaction. In 1985, we conducted a cross\u2010sectional study that demonstrated a positive association between age and stage in response to an <jats:italic>Aedes albopictus<\/jats:italic> bite among 162 healthy volunteers. However, it remains unknown how the mosquito bite reaction stage progresses in the same individual over decades. In the present study, the mosquito bite reaction of 10 subjects from the 1985 cross\u2010sectional cohort was longitudinally evaluated over 30 years. We confirmed the time\u2010dependent progression of stage in four subjects. One stage <jats:styled-content style=\"fixed-case\">II<\/jats:styled-content> subject and three stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> subjects had advanced to the next stage. We went on to find that, contrasting with the general trend found in the previous studies, the majority of the subjects (6\/10) remained of stage <jats:styled-content style=\"fixed-case\">III<\/jats:styled-content> over the 30\u2010year study period. Upon closer inspection, this apparently non\u2010progressive group demonstrated a reduction in the size of the delayed reactions. The present study demonstrated a marked individual variability in course of the stage progression.<\/jats:p>","DOI":"10.1111\/1346-8138.14688","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T16:02:19Z","timestamp":1540396939000},"page":"1471-1474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Study on the correlation between age and changes in mosquito bite response"],"prefix":"10.1111","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8037-6697","authenticated-orcid":false,"given":"Keiko","family":"Oka","sequence":"first","affiliation":[{"name":"Oka Skin Clinic Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Ohtaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kudanzaka Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Igawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical and Dental University Tokyo Japan"},{"name":"Department of Dermatology Dokkyo University Tochigi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroo","family":"Yokozeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/158554c0"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.1949.tb03310.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1989.tb01251.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.06.005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70395-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1989.tb01277.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1989.tb01587.x"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1996.tb00597.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000023907"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000371349"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.002"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01144.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pt.2017.04.003"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14688","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14688","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T02:19:06Z","timestamp":1694744346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,24]]},"references-count":13,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["10.1111\/1346-8138.14688"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14688","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,24]]},"assertion":[{"value":"2018-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}