{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T03:52:46Z","timestamp":1769313166006,"version":"3.49.0"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T00:00:00Z","timestamp":1540944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102017R1D1A1B03032776"],"award-info":[{"award-number":["NRF\u20102017R1D1A1B03032776"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rosacea is thought to be associated with factors involved in metabolic syndrome (MetS). Muscle mass has a beneficial role in preventing MetS, but its link to rosacea remains unknown. We sought to investigate the association between rosacea severity and relative skeletal muscle mass. A cross\u2010sectional study was conducted on subjects who attended a skin check\u2010up program at the Kangbuk Samsung Hospital Health Screening Center between 2014 and 2016. Polarized light photographs of the face were taken and evaluated by two dermatologists. Skeletal muscle mass index (<jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content>, [%] = total skeletal muscle mass [kg] \/ bodyweight [kg] \u00d7 100) was estimated using a bioelectrical impedance analyzer. A logistic regression model was used to evaluate an association between <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> and rosacea. Of 110 rosacea subjects who were finally enrolled, 17 (15.5%) and 93 (84.5%) were classified as having papulopustular and erythematotelangiectatic rosacea, respectively. Categories of <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> comprised the following tertiles: 22.86\u201338.40%, 38.41\u201343.44% and 43.45\u201380.65%. In severity, compared with mild rosacea (75.5%), moderate rosacea (24.5%) incrementally increased as <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> decreased (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> &lt; 0.01). Severe rosacea was not observed. After adjustment for age and sex, odds ratios (95% confidence intervals) for moderate rosacea comparing <jats:styled-content style=\"fixed-case\">SMI<\/jats:styled-content> tertiles 1 and 2 to the highest tertile (reference) were 5.66 (1.22\u201326.20) and 4.43 (1.12\u201317.55), respectively (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.03). This association was present in women with marginal significance (<jats:italic>P<\/jats:italic><jats:sub>trend<\/jats:sub> = 0.06), but not in men. Relative muscle mass is negatively associated with an increased risk of more severe rosacea, suggesting that skeletal muscle can have a protective effect on rosacea exacerbation.<\/jats:p>","DOI":"10.1111\/1346-8138.14689","type":"journal-article","created":{"date-parts":[[2018,10,31]],"date-time":"2018-10-31T15:55:28Z","timestamp":1541001328000},"page":"11-17","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Association between rosacea severity and relative muscle mass: A cross\u2010sectional study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-7390","authenticated-orcid":false,"given":"Jae\u2010Hui","family":"Nam","sequence":"first","affiliation":[{"name":"Department of Dermatology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul Korea"},{"name":"Veterans Medical Research Institute Veterans Health Service Medical Center Seoul 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Occupational and Environmental Medicine School of Medicine Kangbuk Samsung Hospital Seoul Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation SAIHST Sungkyunkwan University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seungho","family":"Ryu","sequence":"additional","affiliation":[{"name":"Center for Cohort Studies Total Healthcare Center Seoul Korea"},{"name":"Department of Occupational and Environmental Medicine School of Medicine Kangbuk Samsung Hospital Seoul Korea"},{"name":"Department of Clinical Research Design &amp; Evaluation SAIHST Sungkyunkwan University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Won\u2010Serk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul 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