{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:12:45Z","timestamp":1763017965735,"version":"3.37.3"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of an 88\u2010year\u2010old Japanese man with erythrodermic involvement of T\u2010cell prolymphocytic leukemia (T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content>). He had a history of pharyngeal diffuse large B\u2010cell lymphoma successfully treated with polychemotherapy including cyclophosphamide and epirubicin, 6 years before the current illness. He presented with numerous reddish, coalescing, flat\u2010topped papules on the trunk and extremities, sparing the skin folds of the abdomen, the features of which mimicked those of papuloerythroderma. Immunohistochemistry showed perivascular and epidermotropic infiltration of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>+<\/jats:sup> T cells in the cutaneous lesion. However, flow cytometric analysis revealed that the skin infiltrating T cells were negative for surface <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4, and that <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>3<jats:sup>+<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>4<jats:sup>\u2212<\/jats:sup> <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>8<jats:sup>\u2212<\/jats:sup> cells made up 92% of the T\u2010cell fraction of peripheral blood. The circulating atypical T cells had a round or oval nucleus and prominent nucleoli, and the deletion of chromosomes 6q, 13 and 17. These cytological profiles were consistent with those of T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content> and distinct from those of S\u00e9zary cells. The same T\u2010cell clone was detected in the cutaneous lesion and peripheral blood, but the expression of <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>62L was absent in the skin infiltrates and present in the circulating cells. No specific mutation was detected in <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>3<\/jats:italic> or <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>5B<\/jats:italic>. Although low\u2010dose oral etoposide had a beneficial effect on the skin rash, a fatal crisis of marked leukocytosis (169 \u00d7 10<jats:sup>3<\/jats:sup>\/\u03bcL) occurred 19 months after the illness onset. <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>62L\u2010leukemic cells of T\u2010<jats:styled-content style=\"fixed-case\">PLL<\/jats:styled-content> may infiltrate the skin to form papuloerythroderma\u2010like cutaneous lesions.<\/jats:p>","DOI":"10.1111\/1346-8138.14702","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T12:02:39Z","timestamp":1542628959000},"page":"65-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Papuloerythroderma\u2010like cutaneous involvement of a <scp>CD<\/scp>62L<sup>\u2212<\/sup> subclone of T\u2010cell prolymphocytic leukemia"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6457-0307","authenticated-orcid":false,"given":"Yuki","family":"Nakagawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4192-5707","authenticated-orcid":false,"given":"Toshihisa","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayuko","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Kanno","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Hematology and Oncology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahide","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Division of Medical Support of Okayama University Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Medical Support of Okayama University Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Okada","sequence":"additional","affiliation":[{"name":"Division of Medical Support of Okayama University Hospital Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Division of Hematology Department of Internal Medicine Shinshu University School of Medicine Matsumoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Miyake","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine Dentistry and Pharmaceutical Sciences Okayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1374-065X","authenticated-orcid":false,"given":"Shin","family":"Morizane","sequence":"additional","affiliation":[{"name":"Department of Dermatology Okayama University Graduate 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