{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T22:57:54Z","timestamp":1780959474099,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T00:00:00Z","timestamp":1542326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective was to evaluate the demographic and clinical characteristics of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c) patients with spinal calcinosis. Paraspinal and intraspinal calcinosis was assessed blindly by orthopedic surgeons specializing in spinal diseases using chest high\u2010resolution computed tomography (<jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>) that was performed for the screening and prospecting of interstitial lung disease in 159 Japanese <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. Among these patients, we identified 27 (17%) with spinal calcinosis, and the most common site was cervical level at 77.8% (21\/27). The frequency of spinal calcinosis in the late stage was higher than in the early stage (44.4% vs 29.6%). Multiple calcinosis was identified in 18.5% (5\/27). The frequency of paraspinal calcinosis only was 59.3%, intraspinal calcinosis only 18.5%, and both intraspinal and paraspinal calcinosis 22.2%. Among <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients, 4.4% (7\/159) had <jats:styled-content style=\"fixed-case\">CT<\/jats:styled-content>\u2010based evidence of spinal cord compression. Among cases with spinal cord compression, only one had neurological symptoms, and surgical removal improved the symptoms. The other six <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with spinal calcinosis (3.8% of 159) had no symptoms. Male sex (29.6%) and severe peripheral vasculopathy such as digital ulcers (55.6%) and acro\u2010osteolysis (33.3%) were significantly more frequent in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with spinal calcinosis than in the <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients without spinal calcinosis (10.6%, 32.6% and 14.4%, respectively). Our results suggest that severe peripheral vasculopathy may be associated with the development of spinal calcinosis. Because <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients are prone to spinal calcinosis, when <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients claim symptoms such as pain, numbness and movement disorder of the extremities, spinal calcinosis is a complication that should be taken into consideration.<\/jats:p>","DOI":"10.1111\/1346-8138.14704","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T07:54:46Z","timestamp":1542441286000},"page":"33-36","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Demographic and clinical characteristics of spinal calcinosis in systemic sclerosis: Possible association with peripheral angiopathy"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-0669","authenticated-orcid":false,"given":"Sei\u2010ichiro","family":"Motegi","sequence":"first","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Sekiguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Yonemoto","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Gunma University Graduate School of Medicine Maebashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokue","family":"Mieda","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery Gunma University Graduate School of Medicine Maebashi 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