{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:25:37Z","timestamp":1773793537016,"version":"3.50.1"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T00:00:00Z","timestamp":1542844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rosacea has been reported to be associated with psychiatric disorders. Nevertheless, a nationwide study of the relationship between rosacea and comorbid psychiatric diseases in an Asian population has not been conducted. The aim of this study was to clarify the role of rosacea in the various psychiatric disorders by using a nationwide database in Taiwan. Data were obtained from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 7881 patients with rosacea and 31\u00a0524 age\u2010 and sex\u2010matched controls were enrolled. Patients with rosacea tended to have more coexisting psychiatric disorders. After adjusting for age, sex, comorbidity and residence\/regions, the adjusted hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) of psychiatric disorders for patients with rosacea was 2.761 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a02.650\u20132.877, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001). Among them, the highest adjusted <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content> are phobic disorder and obsessive\u2013compulsive disorder of 7.841 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a07.526\u20138.170, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001) and 6.389 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a06.132\u20136.657, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.001), respectively. The National Health Insurance Research Database of Taiwan does not include the information about rosacea subtypes, severity and laboratory parameters. In conclusion, rosacea is related to various psychiatric disorders. In addition to anxiety and depression, patients are also at increased risk of phobic disorder and obsessive\u2013compulsive disorder.<\/jats:p>","DOI":"10.1111\/1346-8138.14705","type":"journal-article","created":{"date-parts":[[2018,11,22]],"date-time":"2018-11-22T15:33:42Z","timestamp":1542900822000},"page":"110-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk of psychiatric disorders in rosacea: A nationwide, population\u2010based, cohort study in Taiwan"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-7757","authenticated-orcid":false,"given":"Chih\u2010Tsung","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Dermatology Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"},{"name":"Graduate Institute of Medical Sciences National Defense Medical Center Taipei 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