{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T23:13:43Z","timestamp":1784157223022,"version":"3.55.0"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report herein a case of a 72\u2010year\u2010old man with pityriasis rubra pilaris (<jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>) that was refractory to conventional therapies. His skin lesions progressed to generalized erythroderma despite anti\u2010interleukin (<jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>)\u201017A antibody therapy. Topical corticosteroids, emollients, systemic retinoid, methotrexate, cyclosporin and phototherapy yielded no therapeutic response. However, blockade of <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012\/23 p40 dramatically improved his cutaneous lesions. Complete remission was achieved 4 weeks after the first injection of ustekinumab and maintained for more than 48 weeks. Our data indicate that <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 was associated with the onset of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content> in this patient, rather than <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201023. <jats:styled-content style=\"fixed-case\">IL<\/jats:styled-content>\u201012 is critical for the differentiation of T\u2010helper (Th)1 cells. Thus, the Th1 pathway may be associated with the onset of <jats:styled-content style=\"fixed-case\">PRP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14709","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T09:24:54Z","timestamp":1543829094000},"page":"70-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Case of pityriasis rubra pilaris progressed to generalized erythroderma following blockade of interleukin\u201017A, but improved after blockade of interleukin\u201012\/23 p40"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9426-2973","authenticated-orcid":false,"given":"Tomoko","family":"Matsuda","sequence":"first","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7292-6732","authenticated-orcid":false,"given":"Fumikazu","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Ueda\u2010Hayakawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9610-4952","authenticated-orcid":false,"given":"Naotomo","family":"Kambe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Japan"},{"name":"Allergy Center Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1980.tb01676.x"},{"issue":"5","key":"e_1_2_5_3_1","first-page":"367","article-title":"Secukinumab emerges as a rapidly effective therapy for pityriasis rubra pilaris","volume":"101","author":"Bonomo L","year":"2018","journal-title":"Cutis"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.3885"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2016.09.006"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488902"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdcr.2018.02.007"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09855.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2016.5384"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.3315\/jdcr.2013.1127"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14114"},{"key":"e_1_2_5_12_1","first-page":"224","volume-title":"Lever's Histopathology of the Skin","author":"David E","year":"2014"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000240018"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14709","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14709","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T07:26:35Z","timestamp":1694762795000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1111\/1346-8138.14709"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14709","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]},"assertion":[{"value":"2018-07-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-03","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}