{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:49Z","timestamp":1787013589743,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003345","name":"Chinese Academy of Meteorological Sciences","doi-asserted-by":"publisher","award":["CAMS\u20102017\u201012M\u20101\u2010011"],"award-info":[{"award-number":["CAMS\u20102017\u201012M\u20101\u2010011"]}],"id":[{"id":"10.13039\/501100003345","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic itch with an itch\u2013scratch vicious circle is a significant problem in a large amount of diseases. Some of these diseases, such as psoriasis, atopic dermatitis, prurigo nodularis, S\u00e9zary syndrome, uremic pruritus, diabetes and jaundice, are common. For a very long time, chronic itch has been a thorny problem with few effective treatments. Because of this, itch researchers and dermatologists seek to find the mechanisms among chronic itch, inflammatory cytokines and neurons. As an immediate area of research focus, we are going to find the peripheral cross\u2010talk between neurons and skin cells. Two receptors, named transient receptor potential channel vanilloid 1 and transient receptor potential channel ankyrin transmembrane protein 1, have been shown to play important roles in chronic itch. Many advances have been made so far this decade. This review talks about the updated mechanism of itch\u2010related inflammatory cytokines via transient receptor potential channels in cutaneous chronic itch and corresponding diseases. The search for itch\u2010related inflammatory mediators and the structure of transient receptor potential channels this decade could deepen our understanding of the mechanism of itch and help us find more treatments of chronic itch in the future.<\/jats:p>","DOI":"10.1111\/1346-8138.14749","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T04:10:14Z","timestamp":1545883814000},"page":"177-185","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Inflammatory mediators causing cutaneous chronic itch in some diseases via transient receptor potential channel subfamily V member 1 and subfamily A member 1"],"prefix":"10.1111","volume":"46","author":[{"given":"Bo","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Pharmacology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-7528","authenticated-orcid":false,"given":"Xin\u2010Yu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,12,27]]},"reference":[{"key":"e_1_2_17_2_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1159"},{"key":"e_1_2_17_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-015-8488-5"},{"key":"e_1_2_17_4_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.8659.1"},{"key":"e_1_2_17_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0284185115604514"},{"key":"e_1_2_17_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009555"},{"key":"e_1_2_17_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-017-0395-5"},{"key":"e_1_2_17_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.09.036"},{"key":"e_1_2_17_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsi.2015.10.002"},{"key":"e_1_2_17_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf4918"},{"key":"e_1_2_17_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2014.04.007"},{"key":"e_1_2_17_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12822"},{"key":"e_1_2_17_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000134"},{"key":"e_1_2_17_14_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201511354"},{"key":"e_1_2_17_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146451"},{"key":"e_1_2_17_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14367"},{"key":"e_1_2_17_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609598103"},{"key":"e_1_2_17_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmpt.2013.05.018"},{"key":"e_1_2_17_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019755108"},{"key":"e_1_2_17_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2789"},{"key":"e_1_2_17_21_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5318-12.2013"},{"key":"e_1_2_17_22_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1817VV"},{"key":"e_1_2_17_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2992-10.2011"},{"key":"e_1_2_17_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-18187-z"},{"key":"e_1_2_17_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2013.02.010"},{"key":"e_1_2_17_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12317"},{"key":"e_1_2_17_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2013.10.048"},{"key":"e_1_2_17_28_1","first-page":"1682972","article-title":"TRPV1 and PLC participate in histamine H4 receptor\u2010induced itch","volume":"2016","author":"Tunyu J","year":"2016","journal-title":"Neural Plast"},{"key":"e_1_2_17_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13533"},{"key":"e_1_2_17_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071485"},{"key":"e_1_2_17_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13343"},{"key":"e_1_2_17_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.767"},{"key":"e_1_2_17_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.018"},{"key":"e_1_2_17_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.08.006"},{"key":"e_1_2_17_35_1","doi-asserted-by":"publisher","DOI":"10.1358\/dot.2017.53.9.2693150"},{"key":"e_1_2_17_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2014.07.008"},{"key":"e_1_2_17_37_1","unstructured":"Clinicaltrials.gov[https:\/\/www.clinicaltrials.gov\/]. A Study ofLebrikizumab in Participants With Persistent Moderate to Severe Atopic Dermatitis. [Cited 2018 June 14]. Available from:https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT02340234?term=Lebrikizumab&rank=9."},{"key":"e_1_2_17_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.037"},{"key":"e_1_2_17_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.242"},{"key":"e_1_2_17_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600893"},{"key":"e_1_2_17_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.768"},{"key":"e_1_2_17_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2018.01.016"},{"key":"e_1_2_17_43_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2047"},{"key":"e_1_2_17_44_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.32036"},{"key":"e_1_2_17_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-014-1068-z"},{"key":"e_1_2_17_46_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4643-06.2007"},{"key":"e_1_2_17_47_1","doi-asserted-by":"publisher","DOI":"10.5114\/ada.2017.71112"},{"key":"e_1_2_17_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.020"},{"key":"e_1_2_17_49_1","unstructured":"Clinicaltrials.gov[https:\/\/www.clinicaltrials.gov\/].A Study of Intravenous MK\u20108226 in Participants With Moderate\u2010to\u2010Severe Atopic Dermatitis (MK\u20108226\u2010003). [Cited 2018 June 14]. Available from:https:\/\/www.clinicaltrials.gov\/ct2\/show\/NCT01732510?term=MK8226&draw=1&rank=1."},{"key":"e_1_2_17_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2014.02.007"},{"issue":"2","key":"e_1_2_17_51_1","first-page":"211","article-title":"Role of interleukin\u20102 uremic pruritus among attendants of Al\u2010Zahraa Hospital dialysis unit","volume":"60","author":"Azim AA","year":"2015","journal-title":"Indian J Dermatol"},{"issue":"6","key":"e_1_2_17_52_1","first-page":"353","article-title":"Regulation of T cell immunity in atopic dermatitis by microbes: the Yin and Yang of cutaneous inflammation","volume":"13","author":"Biedermann T","year":"2015","journal-title":"Front Immunol"},{"key":"e_1_2_17_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-44605-8_18"},{"key":"e_1_2_17_54_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00109"},{"key":"e_1_2_17_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.12.023"},{"key":"e_1_2_17_56_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2015.1008449"},{"key":"e_1_2_17_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2008.01.024"},{"key":"e_1_2_17_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgr037"},{"key":"e_1_2_17_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-017-9407-8"},{"key":"e_1_2_17_60_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1400"},{"key":"e_1_2_17_61_1","doi-asserted-by":"publisher","DOI":"10.1159\/000446012"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14749","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14749","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T01:27:10Z","timestamp":1694654830000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14749"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,27]]},"references-count":60,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/1346-8138.14749"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14749","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,27]]},"assertion":[{"value":"2018-08-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-12-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}