{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T04:48:29Z","timestamp":1785473309304,"version":"3.56.0"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009857","name":"Regeneron Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009857","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Moderate to severe atopic dermatitis (<jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>) has a high disease burden and a significant effect on quality of life. Observational studies are necessary to determine the patient disease burden and long\u2010term disease control in the Japanese population. <jats:styled-content style=\"fixed-case\">ADDRESS<\/jats:styled-content>\u2010J is a non\u2010interventional, observational registry of adult Japanese patients with moderate to severe <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. Herein, we report baseline data from the <jats:styled-content style=\"fixed-case\">ADDRESS<\/jats:styled-content>\u2010J study describing disease characteristics and current treatment practices. At baseline, 300 adult <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> patients with Investigator's Global Assessment (<jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content>) scores (range, 0\u20134) of 3 (moderate) or 4 (severe) whose treatments for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> were intensified, were assessed for clinical and patient\u2010reported outcomes and current <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> treatments. The registry patients\u2019 median age was 34.0\u00a0years; 60.7% were male and 71.7% had had <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> for more than 20\u00a0years. At baseline, 220 study patients had an <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> score of 3 and 80 had an <jats:styled-content style=\"fixed-case\">IGA<\/jats:styled-content> score of 4. The median Eczema Area and Severity Index score was 21.7 (range, 0\u201372), the median body surface area involvement was 46.25%, and the median pruritus numerical rating scale score was 7.0 (range, 0\u201310); for each of these measures, higher scores represent greater severity. Most registry patients (86.7%) had recently used topical corticosteroids or topical calcineurin inhibitors as treatment for <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>. This registry cohort represents a population of Japanese patients with moderate to severe <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> and provides an important resource for characterizing the disease burden and evaluating the safety and effectiveness of various <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content> treatments.<\/jats:p>","DOI":"10.1111\/1346-8138.14787","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T10:35:42Z","timestamp":1550054142000},"page":"290-300","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Atopic dermatitis disease registry in Japanese adult patients with moderate to severe atopic dermatitis (<scp>ADDRESS<\/scp>\u2010J): Baseline characteristics, treatment history and disease burden"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3498-2482","authenticated-orcid":false,"given":"Norito","family":"Katoh","sequence":"first","affiliation":[{"name":"Department of Dermatology Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1095-0355","authenticated-orcid":false,"given":"Hidehisa","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nippon Medical School Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka Habikino Medical Center Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Etoh","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Teishin Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-0597","authenticated-orcid":false,"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Kyoto Prefectural University of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Takagi","sequence":"additional","affiliation":[{"name":"Sanofi K.K. 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