{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T10:07:38Z","timestamp":1781863658868,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP18fk0108008"],"award-info":[{"award-number":["JP18fk0108008"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"Abstract<\/jats:title>Trichophyton interdigitale<\/jats:italic> is an anthropophilic species that is frequently isolated from tinea unguium and tinea pedis throughout the world. In the present study, antifungal susceptibility testing was performed on T. interdigitale<\/jats:italic> isolates from Japanese patients (isolated in 2017\u20132018; 24 strains) to assess itraconazole (ITZ<\/jats:styled-content>) and terbinafine (TRF<\/jats:styled-content>) susceptibility of these strains. E\u2010test determinations revealed that the mean ITZ<\/jats:styled-content> minimum inhibitory concentration (MIC<\/jats:styled-content>) of the 24 strains was 0.023 mg\/L (range, 0.064\u20131). Clinical Laboratory Standards Institute M38\u2010A2 determinations revealed that the mean TRF MIC<\/jats:styled-content> of 23 of the 24 strains was less than 0.03125 mg\/L. Among these strains, one (NUBS<\/jats:styled-content>18016) had a TRF MIC<\/jats:styled-content> of 2 mg\/L, confirming its resistance to TRF<\/jats:styled-content>. The predicted amino acid sequences of the squalene epoxidase (SQLE<\/jats:styled-content><\/jats:italic>) gene from the TRF<\/jats:styled-content>\u2010resistant strain (NUBS<\/jats:styled-content>18016) was 100% identical to the SQLE<\/jats:styled-content><\/jats:italic> gene sequence of the reference strain T. interdigitale<\/jats:italic>, indicating that no gene mutations were present in NUBS<\/jats:styled-content>18016. Therefore, the TRF<\/jats:styled-content>\u2010resistance mechanism of our TRF<\/jats:styled-content>\u2010resistant strain NUBS<\/jats:styled-content>18016 has not been defined. Dermatologists should be cautious about the prevalence of foot dermatophytosis due to antifungal drug\u2010resistant strains.<\/jats:p>","DOI":"10.1111\/1346-8138.14809","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T15:13:07Z","timestamp":1550243587000},"page":"351-353","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Terbinafine\u2010resistant strain of Trichophyton interdigitale<\/i> strain isolated from a tinea pedis patient"],"prefix":"10.1111","volume":"46","author":[{"given":"Junichiro","family":"Hiruma","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Kitagawa","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology Nihon University College of Bioresource Sciences Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4993-304X","authenticated-orcid":false,"given":"Hiromitsu","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Noguchi Dermatology Clinic Kumamoto Japan"},{"name":"Ochanomizu Institute for Medical Mycology and Allergology Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1764-629X","authenticated-orcid":false,"given":"Rui","family":"Kano","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology Nihon University College of Bioresource Sciences Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masataro","family":"Hiruma","sequence":"additional","affiliation":[{"name":"Ochanomizu Institute for Medical Mycology and Allergology Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kamata","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology Nihon University College of Bioresource Sciences Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-4097","authenticated-orcid":false,"given":"Kazutoshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"105","volume-title":"Medical Mycology","author":"Kwon\u2010Chung KJ","year":"1992"},{"key":"e_1_2_7_3_1","first-page":"527","volume-title":"Fundamental Medical Mycology","author":"Reiss E","year":"2012"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-013-9655-y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00115-17"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.43.5.2092-2103.2005"},{"key":"e_1_2_7_7_1","volume-title":"Etest Technical Guide 10. 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