{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:41Z","timestamp":1780921781514,"version":"3.54.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"Abstract<\/jats:title>\n \n Palmoplantar pustulosis (\n PPP<\/jats:styled-content>\n ) and pompholyx are both chronic and relapsing diseases occurring on the palms and soles. Although these two diseases have been considered completely different from each other, it is sometimes very difficult even for dermatologists to differentiate them from each other because of their similarities in clinical presentation. In this study, we aimed to analyze the histopathological features of\n PPP<\/jats:styled-content>\n and pompholyx and find out \u201cclues\u201d to differentiate between\n PPP<\/jats:styled-content>\n and pompholyx by their histopathological features. The histopathology of 11\n PPP<\/jats:styled-content>\n and six pompholyx patients, who were diagnosed with typical clinical history and histopathology, were carefully observed.\n PPP<\/jats:styled-content>\n cases were divided into three phases (vesicle, pustulovesicule and pustule) and pompholyx cases were divided into two phases (vesicle and pustule), and histopathological findings and a 4\u2010point checklist to distinguish between\n PPP<\/jats:styled-content>\n and pompholyx were preliminarily established. To confirm whether the checklist establishes the clues for diagnosis, biopsy samples from 43 patients (32\n PPP<\/jats:styled-content>\n and 11 pompholyx) who had been already diagnosed at five hospitals were examined according to our checklist without any additional clinical information. According to our 4\u2010point checklist, 31 of 32\n PPP<\/jats:styled-content>\n patients and all 11 pompholyx patients were diagnosed histopathologically consistent with their clinical diagnosis. In conclusion, histopathological findings of \u201cvesicles without spongiosis\u201d and \u201cmicroabscess on the edges of vesicles\u201d would be impact points for the differential diagnosis between\n PPP<\/jats:styled-content>\n and pompholyx. The 4\u2010point checklist was trustworthy to distinguish between\n PPP<\/jats:styled-content>\n and pompholyx.\n <\/jats:p>","DOI":"10.1111\/1346-8138.14850","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T04:53:00Z","timestamp":1553748780000},"page":"399-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Diagnostic histopathological features distinguishing palmoplantar pustulosis from pompholyx"],"prefix":"10.1111","volume":"46","author":[{"given":"Kana","family":"Masuda\u2010Kuroki","sequence":"first","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-5096","authenticated-orcid":false,"given":"Masamoto","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-1756","authenticated-orcid":false,"given":"Mari","family":"Kishibe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seibo Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9526-1259","authenticated-orcid":false,"given":"Yukari","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8390-2573","authenticated-orcid":false,"given":"Toshiyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fukushima Medical University Fukushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Terui","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nihon University School of Medicine Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Sayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ehime University Graduate School of Medicine Toon Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1974.01630040028005"},{"key":"e_1_2_7_3_1","first-page":"1489","volume-title":"Fitzpatrick's Dermatology in General Medicine","author":"John D","year":"1999"},{"key":"e_1_2_7_4_1","first-page":"76","article-title":"Pustulosis palmoplantaris. How initial ultrastructural alterations change into vesicles and pustules","volume":"146","author":"Bacharach BM","year":"1989","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2009.05.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2012.04602.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-197900130-00002"},{"key":"e_1_2_7_8_1","first-page":"4","article-title":"Disease state and medical treatment of PPP","volume":"1","author":"Terui T","year":"2016","journal-title":"PPP Frontier"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.13846"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02113.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2015.02.006"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.87"},{"key":"e_1_2_7_13_1","first-page":"137","volume-title":"Skin Pathology","author":"Weedon D","year":"2002"},{"key":"e_1_2_7_14_1","first-page":"111","volume-title":"Skin Pathology","author":"Weedon D","year":"2002"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2009.03383.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1952.tb15875.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198604000-00004"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14850","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.14850","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1111%2F1346-8138.14850","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14850","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:41:46Z","timestamp":1694353306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14850"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1111\/1346-8138.14850"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14850","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735413777.793586733","asserted-by":"object"}]},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]},"assertion":[{"value":"2018-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}