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Ipilimumab is another immune checkpoint inhibitor (<jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content>) that activates and increases T cells, which suppress the function of regulatory T cells. Previous reports have suggested that ipilimumab is useful for treating advanced melanoma, particularly in combination with radiation therapy. In this report, we described three cases of nivolumab\u2010resistant melanoma successfully controlled by ipilimumab with intensity\u2010modulated radiotherapy, which may enhance the therapeutic effects of the sequential administration of <jats:styled-content style=\"fixed-case\">ICI<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14861","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T20:14:28Z","timestamp":1553544868000},"page":"449-452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Three cases of nivolumab therapy\u2010failed advanced melanoma successfully controlled by ipilimumab with intensity\u2010modulated radiotherapy"],"prefix":"10.1111","volume":"46","author":[{"given":"Ryo","family":"Amagai","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai 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