{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:39:48Z","timestamp":1787013588823,"version":"build-2736575974"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pulse corticosteroid therapy is effective for alopecia areata (\n                    <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                    ) in the early stage. The risk and efficacy of this therapy for patients with several backgrounds, however, remains controversial. To explore the predictive factors of the response and risk factors of this therapy, data from 105\n                    <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                    patients treated with methylprednisolone (500\u00a0mg) i.v. for 3\u00a0days consecutively in our facility were retrospectively analyzed. Among good responders, longer time from the onset to therapy was correlated with longer time required for hair regrowth (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.037,\n                    <jats:italic>n\u00a0<\/jats:italic>\n                    =\n                    <jats:italic>\u00a0<\/jats:italic>\n                    27). Multivariate models demonstrated that \u201cseverity\u201d, \u201crelapse\u201d and longer \u201cduration from the latest onset\u201d were significantly and independently associated with poorer outcome (\n                    <jats:italic>P\u00a0<\/jats:italic>\n                    &lt;\n                    <jats:italic>\u00a0<\/jats:italic>\n                    0.01). \u201cHistory of atopic dermatitis (\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    )\u201d was also associated with poorer outcome, but this correlation could be explained by the effect that duration from the latest onset of\n                    <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                    was longer among participants with\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    . We propose that earlier initiation of pulse corticosteroid therapy is preferable for better outcome of\n                    <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>\n                    , particularly among patients with\n                    <jats:styled-content style=\"fixed-case\">AD<\/jats:styled-content>\n                    . Clinicians should be mindful of the occurrence of mild adverse effects in the elderly patients.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.14871","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T10:46:58Z","timestamp":1554893218000},"page":"522-525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Predictive factors of response to pulse methylprednisolone therapy in patients with alopecia areata: A follow\u2010up study of 105 Japanese patients"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9969-7757","authenticated-orcid":false,"given":"Hiroko","family":"Fujii","sequence":"first","affiliation":[{"name":"Department of Dermatology Shiga General Hospital Shiga Japan"},{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuichiro","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9497-0029","authenticated-orcid":false,"given":"Teruki","family":"Dainichi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Otsuka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Fujisawa Dermatology Clinic Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Tanioka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Tanioka Dermatology Clinic Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiki","family":"Miyachi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Shiga General Hospital Shiga Japan"},{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0773-0554","authenticated-orcid":false,"given":"Kenji","family":"Kabashima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan"},{"name":"Singapore Immunology Network (SIgN) and Institute of Medical Biology Agency for Science, Technology and Research (A*STAR) Biopolis Singapore City Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.232"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01135.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2340\/000155555493496","article-title":"Large doses of glucocorticoid in the treatment of alopecia areata","volume":"55","author":"Burton JL","year":"1975","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70009-X"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000051642"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000107626"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.1.6.11236"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000341523"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12637"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13388"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10955.x"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2003.09.032"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2006.01676.x"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2015.09.045"},{"issue":"13","key":"e_1_2_6_16_1","first-page":"2741","article-title":"Guidelines for the management of alopecia areata","volume":"127","author":"Tsuboi R","year":"2017","journal-title":"Jpn J Dermatol"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14871","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.14871","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14871","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T14:54:42Z","timestamp":1694357682000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/1346-8138.14871"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14871","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,10]]},"assertion":[{"value":"2018-08-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}