{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T23:38:19Z","timestamp":1773617899851,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 67\u2010year\u2010old man, who had been diagnosed with psoriasis 30\u00a0years prior, visited our hospital with a complaint of verrucous nodules in the lower legs, which had developed 15\u00a0years previously. We diagnosed him as having psoriasis verrucosa of the legs and plaque psoriasis of the torso. Because the lesions were resistant to topical glucocorticoids and vitamin D<jats:sub>3<\/jats:sub>, a verrucous lesion in the right leg was treated with surgical ablation, which resulted in the development of generalized pustular psoriasis. After pustular lesions were cleared by systemic glucocorticoids and methotrexate, we treated him with etretinate and cyclosporin, but the verrucous lesions accompanied by chronic bacterial infection persisted over time. One year ago, treatment with recently\u2010approved apremilast was started. It immediately attenuated the plaques and erythropapular lesions of the trunk. Surprisingly, the verrucous nodules of both legs showed reduction in size in 2\u00a0months.<\/jats:p>","DOI":"10.1111\/1346-8138.14877","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T09:30:18Z","timestamp":1554715818000},"page":"544-547","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Favorable response to apremilast in a patient with refractory psoriasis verrucosa"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4837-1519","authenticated-orcid":false,"given":"Sari","family":"Okazaki","sequence":"first","affiliation":[{"name":"Department of Dermatology Kochi Medical School Kochi University Nankoku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Osawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kochi Medical School Kochi University Nankoku 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