{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:55:29Z","timestamp":1776862529103,"version":"3.51.2"},"reference-count":9,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hypereosinophilic syndrome (<jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>) is often associated with cutaneous manifestations, mostly pruritic lesions, urticaria and angioedema. Mucosal lesions are rarely seen in <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content> but, when present, are usually the first manifestation of the disease. The clinical presentation may be heterogeneous, including erosions, aphthae or ulcers, and can be easily confused with other mucocutaneous disorders. Here, we present the case of a 64\u2010year\u2010old man with severe chronic erosive oral mucositis simulating pemphigus in which the finding of persistent eosinophilia and elevation of B<jats:sub>12<\/jats:sub> vitamin serum levels raised the suspicion of <jats:styled-content style=\"fixed-case\">HES<\/jats:styled-content>. The <jats:italic><jats:styled-content style=\"fixed-case\">FIP<\/jats:styled-content>1L1\u2013<jats:styled-content style=\"fixed-case\">PDGFRA<\/jats:styled-content><\/jats:italic> fusion gene (4q12) was detected by fluorescence <jats:italic>in\u00a0situ<\/jats:italic> hybridization and the patient was treated with imatinib mesylate with complete response of the disease.<\/jats:p>","DOI":"10.1111\/1346-8138.14888","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T10:46:40Z","timestamp":1556189200000},"page":"531-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pemphigus\u2010like hypereosinophilic syndrome with <i><scp>FIP<\/scp>1L1\u2013<scp>PDGFRA<\/scp><\/i> fusion gene: A challenging and uncommon clinical presentation"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7387-4257","authenticated-orcid":false,"given":"Laia","family":"Curto\u2010Barredo","sequence":"first","affiliation":[{"name":"Department of Dermatology Hospital del Mar\u2010Parc de Salut Mar Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Segura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar\u2010Parc de Salut Mar Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norito","family":"Ishii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kurume University School of Medicine Kurume Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka City University Graduate School of Medicine Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Jos\u00e9 M.","family":"Mascar\u00f3","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital Clinic de Barcelona University of Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Espinet","sequence":"additional","affiliation":[{"name":"Molecular Cytogenetics Laboratory Department of Pathology Hospital del Mar\u2010Parc de Salut Mar Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carles","family":"Besses","sequence":"additional","affiliation":[{"name":"Department of Hematology Hospital del Mar\u2010Parc de Salut Mar Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon M.","family":"Pujol","sequence":"additional","affiliation":[{"name":"Department of Dermatology Hospital del Mar\u2010Parc de Salut Mar Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.revmed.2009.05.008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa025217"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-10-050054"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.03.017"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2007.01393.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.247.7.1018"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-213266"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2011.11.017"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2014.11.001"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14888","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.14888","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14888","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T18:54:38Z","timestamp":1694372078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14888"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,25]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["10.1111\/1346-8138.14888"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14888","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,25]]},"assertion":[{"value":"2018-10-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}