{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:55:10Z","timestamp":1759938910872,"version":"3.40.5"},"reference-count":14,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Pegylated liposomal doxorubicin (<jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>) is an anthracycline anticancer agent used in ovarian cancer and a form of doxorubicin enclosed in pegylated liposomes. There are only a few reports on intertrigo\u2010like eruptions caused by <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>. We describe the first case of severe bullous erythema, including intertrigo\u2010like eruptions with angioedema, induced by <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content> in Japan. We present the case of a 53\u2010year\u2010old woman who was diagnosed with stage <jats:styled-content style=\"fixed-case\">IIIC<\/jats:styled-content> ovarian cancer. After receiving three cycles of <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>, the patient developed swelling of the upper lip and painful erythema with blisters and erosions on the axilla, upper back, flank and wrists. The patient was diagnosed with angioedema and severe skin lesions, including intertrigo\u2010like eruptions induced by <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content>. Although treatment with oral prednisolone and topical steroids was effective against these eruptions, the administration of <jats:styled-content style=\"fixed-case\">PLD<\/jats:styled-content> was discontinued because of its ineffectiveness against the primary disease. Several risk factors, such as obesity, perspiration and racial differences, may contribute toward a severe manifestation such as that seen in our patient. Moreover, our case was the first accompanied by angioedema. The mechanism of coexistence of intertrigo\u2010like eruptions and angioedema is not clear; further studies are required to clarify the pathological mechanism of intertrigo\u2010like eruptions.<\/jats:p>","DOI":"10.1111\/1346-8138.14895","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T11:25:49Z","timestamp":1556191549000},"page":"535-539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Case of severe bullous erythema including intertrigo\u2010like eruptions with angioedema induced by pegylated liposomal doxorubicin"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1478-2897","authenticated-orcid":false,"given":"Michiru","family":"Totsuka","sequence":"first","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University Graduate School of Medicine Yokohama 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