{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:29:06Z","timestamp":1790281746316,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T00:00:00Z","timestamp":1557187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007225","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007225","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis may coexist with bullous pemphigoid (<jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>); however, no cohort studies have investigated the relationship between psoriasis and the risk of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>. This study aims to investigate the relationship between psoriasis and the risk of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> in Taiwan. This cohort study consists of 109 777 psoriatic patients and 109 777 matched non\u2010exposed controls. Psoriatic patients diagnosed between 2002 and 2012 were identified from the Taiwan National Health Insurance Research Database. The age\u2010, sex\u2010 and index date\u2010matched non\u2010exposed group was selected from the same database. The relationship between psoriasis and the risk of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was investigated using Cox proportional hazards analyses. Psoriasis was significantly associated with an increased risk of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> (hazard ratio, 3.05; 95% confidence interval, 2.10\u20134.43; <jats:italic>P<\/jats:italic> &lt; 0.001). The mean interval between the diagnoses of psoriasis and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> was 2.86 years, with the highest occurrence in the first year after psoriasis diagnosis, and gradually decreasing with each year of observation. Psoriatic patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> were significantly younger than <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> patients in the non\u2010exposed group (71.6 \u00b1 13.9 vs 76.6 \u00b1 7.7 years, respectively; <jats:italic>P<\/jats:italic> = 0.030). A higher proportion of patients with coexisting psoriasis and <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> received phototherapy (20%). In conclusion, psoriasis was independently associated with a 3.05\u2010fold increased risk of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>, and psoriatic patients with <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> were younger, with over one\u2010third of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content> cases diagnosed in the first year after incident psoriasis. Therefore, clinicians treating patients with psoriasis may be aware of the possibility of the development of <jats:styled-content style=\"fixed-case\">BP<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14902","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T08:25:02Z","timestamp":1557217502000},"page":"604-609","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Psoriasis is associated with increased risk of bullous pemphigoid: A nationwide population\u2010based cohort study in Taiwan"],"prefix":"10.1111","volume":"46","author":[{"given":"Yi\u2010Hsin","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao\u2010Yun","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Public Health and Department of Public Health National Yang\u2010Ming University Taipei Taiwan"},{"name":"Departments of Education and Research Taipei City Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Ting","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Yang\u2010Ming University School of Medicine Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Pin","family":"Li","sequence":"additional","affiliation":[{"name":"National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Divisions of Gastroenterology and Hepatology Department of Medicine Taipei Veterans General Hospital Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8393-3900","authenticated-orcid":false,"given":"Chen\u2010Yi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Taipei Veterans General Hospital Taipei Taiwan"},{"name":"National Yang\u2010Ming University School of Medicine Taipei Taiwan"},{"name":"Institute of Public Health and Department of Public Health National Yang\u2010Ming University Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.96707"},{"key":"e_1_2_7_3_1","first-page":"301","article-title":"PUVA induced bullous pemphigoid in a patient with psoriasis","volume":"22","author":"Marek\u2010Jozefowicz L","year":"2014","journal-title":"Acta Dermatovenerol 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