{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:20:33Z","timestamp":1747182033747,"version":"3.40.5"},"reference-count":11,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T00:00:00Z","timestamp":1558310400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>) is a rare condition, causing life\u2010threatening adverse cutaneous reactions. <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> occurrence after bone marrow transplantation (<jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content>) is a well\u2010known phenomenon; however, to date, only a few cases have been reported in the published work. Here, we describe the case of a 53\u2010year\u2010old woman who experienced <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> after undergoing allogenic <jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content> for malignant lymphoma. Skin erosion spread across a maximum of 70% of the body surface area and severe mucosal lesions developed. Steroid pulse therapy, plasma apheresis and immunoglobulin therapy were administrated, which resulted in the complete resolution of <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>. However, she developed hemophagocytic lymphohistiocytosis and died 38\u00a0days after <jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content>, owing to rupture of the lower digestive tract complicated by multi\u2010organ failure. In our case, engraftment failure occurred, and the peripheral white blood cell count was less than 100\/\u03bcL during the <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> course, suggesting that the presence of only a few immune cells could cause <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>. Our findings showed that high mortality rates and widespread skin erosion could be regarded as the most important characteristics of <jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> occurring after <jats:styled-content style=\"fixed-case\">BMT<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14913","type":"journal-article","created":{"date-parts":[[2019,5,20]],"date-time":"2019-05-20T09:31:19Z","timestamp":1558344679000},"page":"540-543","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Case of toxic epidermal necrolysis occurring after bone marrow transplantation accompanied by engraftment failure"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2714-5248","authenticated-orcid":false,"given":"Chika","family":"Asai","sequence":"first","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8650-1591","authenticated-orcid":false,"given":"Junko","family":"Mukaijo","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0673-7903","authenticated-orcid":false,"given":"Tomoko","family":"Okawa","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0297-6627","authenticated-orcid":false,"given":"Yukie","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Environmental Immuno\u2010Dermatology Yokohama City University School of Medicine Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayako","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Stem Cell and Immune Regulation Yokohama City University Graduate School of Medicine Yokohama 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