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Because <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>14\u2010mediated biological processes seem to be involved in the development of systemic sclerosis (<jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c), which is characterized by Th2\/Th17\u2010skewed immune polarization and impaired neovascularization, we investigated the clinical correlation of serum <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>14 levels in patients with this disease. Serum <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>14 levels were significantly decreased in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients compared with healthy individuals and in diffuse cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients relative to limited cutaneous <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients. <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with digital ulcers had serum <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>14 levels significantly lower than those without. Furthermore, i.v. cyclophosphamide pulse significantly increased serum <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>14 levels as compared with the baseline in <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c patients with interstitial lung disease successfully treated with this therapy. These results indicate that decreased <jats:styled-content style=\"fixed-case\">CXCL<\/jats:styled-content>14 expression may contribute to the maintenance of Th2\u2010skewed immune polarization and dysregulated neovascularization, both of which underlie the developmental process of <jats:styled-content style=\"fixed-case\">SS<\/jats:styled-content>c.<\/jats:p>","DOI":"10.1111\/1346-8138.14914","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T09:41:19Z","timestamp":1557826879000},"page":"584-589","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Possible association of decreased serum <scp>CXCL<\/scp>14 levels with digital ulcers in patients with systemic sclerosis"],"prefix":"10.1111","volume":"46","author":[{"given":"Yuki","family":"Fukui","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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