{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:36:34Z","timestamp":1787981794105,"version":"build-2784847793"},"reference-count":52,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sarcoidosis and systemic sclerosis (SSc) are both multisystem disorders of unknown etiology. Some cases having both sarcoidosis and SSc have been reported previously. The present study was to investigate clinical features in sarcoidosis patients who possessed SSc\u2010specific autoantibody. The pathophysiology of each disease, including shared pathways leading to the development of both conditions, is reviewed in addition to previous reports of patients with concomitant SSc and sarcoidosis. SSc\u2010specific autoantibodies including anticentromere antibody (ACA), anti\u2010topoisomerase I antibody, anti\u2010RNA polymerase III antibody and anti\u2010U1RNP antibody were examined in sarcoidosis patients. Complete medical histories, clinical examinations and laboratory tests were conducted for all patients. For reviewing previously published reports, all cases were retrieved through a PubMed search. ACA was most frequently observed in sarcoidosis patients. Plaques and papules were the most frequent as the cutaneous sarcoidosis lesions. Soluble interleukin\u20102 receptor was elevated in most of the cases (6\/8, 75%), and thymus and activation\u2010regulated chemokine (TARC) was elevated in all cases (6\/6, 100%). Together with our two cases (cases 1 and 3), a review of previously reported cases of sarcoidosis patients concomitant with SSc showed high frequency of ACA and plaques as cutaneous lesions. We suppose that TARC may play some roles in the production of SSc\u2010specific autoantibodies and development of concomitance with SSc in sarcoidosis, although the mechanisms remain unknown.<\/jats:p>","DOI":"10.1111\/1346-8138.14932","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T10:13:15Z","timestamp":1558951995000},"page":"577-583","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Clinical characteristics of sarcoidosis patients with systemic sclerosis\u2010specific autoantibody: Possible involvement of thymus and activation\u2010regulated chemokine and a review of the published works"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-5691","authenticated-orcid":false,"given":"Ikuko","family":"Ueda\u2010Hayakawa","sequence":"first","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8978-6182","authenticated-orcid":false,"given":"Chuyen Thi Hong","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Osaka Japan"},{"name":"Department of Dermatology and Venereology University of Medicine and Pharmacy Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izumi","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nhung Thi My","family":"Ly","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kansai Medical University Hirakata Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200001000-00012"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0049-0172(92)90043-D"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00063198-200209000-00019"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70296-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-200011000-00011"},{"issue":"48","key":"e_1_2_6_7_1","first-page":"53","article-title":"Hypothesis for the pathogenesis of systemic sclerosis","volume":"24","author":"Furst DE","year":"1997","journal-title":"J Rheumatol"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2007.12.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199511000-00013"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780230602"},{"key":"e_1_2_6_11_1","first-page":"881","article-title":"Sarcoidosis in systemic sclerosis: report of 7 cases","volume":"22","author":"Cox D","year":"1995","journal-title":"J Rheumatol"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.49.3457"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.36.435"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/36.1.117"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-0172(79)80003-7"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1993.tb03828.x"},{"key":"e_1_2_6_17_1","first-page":"71","article-title":"The CREST syndrome and sarcoidosis. 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