{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:18:53Z","timestamp":1779110333673,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Kaken Pharmaceutical Co., Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We evaluated the efficacy of efinaconazole 10% topical solution in long\u2010term use, for up to 72\u00a0weeks, for onychomycosis, including severe cases. Among 605 participants, 219 patients diagnosed as having onychomycosis were evaluated for the efficacy of efinaconazole. The treatment success rate (&lt;10% clinical involvement of the target toenail) at the final assessment time point was 56.6%, the complete cure rate was 31.1% and the mycological cure rate was 61.6%, all of which increased over time, demonstrating that continuous application contributed to the improvement of cure rate. Even in severe cases, reduction of the affected nail area was observed, showing the potential efficacy of the treatment. Responses to a quality of life questionnaire among patients with onychomycosis, OnyCOE\u2010t, suggested that efinaconazole treatment improved the patients\u2019 quality of life. The incidence of adverse drug reaction in the patients eligible for the assessment was 6.3%, and this developed only in the administration site in all cases. No systemic adverse event was observed. In addition, no increase in the incidence of adverse drug reaction due to long\u2010term use was found. Efinaconazole therapy was proved to exhibit excellent balance between efficacy and safety, and thus may serve as a useful treatment option for onychomycosis.<\/jats:p>","DOI":"10.1111\/1346-8138.14935","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T16:30:00Z","timestamp":1560789000000},"page":"641-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Efficacy of long\u2010term treatment with efinaconazole 10% solution in patients with onychomycosis, including severe cases: A multicenter, single\u2010arm study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5806-4355","authenticated-orcid":false,"given":"Ken","family":"Iozumi","sequence":"first","affiliation":[{"name":"Department of Dermatology Tokyo Metropolitan Police Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8863-9428","authenticated-orcid":false,"given":"Masatoshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Sapporo Skin Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Ito Skin Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Uesugi","sequence":"additional","affiliation":[{"name":"Uesugi Dermatology Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Onoduka","sequence":"additional","affiliation":[{"name":"Asanuma Dermatology Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Eniwa Station Dermatology Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumihiro","family":"Kato","sequence":"additional","affiliation":[{"name":"Kato Dermatology Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuo","family":"Kodama","sequence":"additional","affiliation":[{"name":"Megumino Dermatologic Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidetoshi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Takagi Dermatological Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Takeda Dermatological Skin Care Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koki","family":"Tomizawa","sequence":"additional","affiliation":[{"name":"Nopporo Dermatology Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5299-2756","authenticated-orcid":false,"given":"Tomoko","family":"Nomiyama","sequence":"additional","affiliation":[{"name":"Showa Skin Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-1071","authenticated-orcid":false,"given":"Mizue","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Hospital Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Mayama","sequence":"additional","affiliation":[{"name":"Chitose Dermatology and Plastic Surgery Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Muramoto","sequence":"additional","affiliation":[{"name":"Shinoro Dermatology Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidemi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Fukuzumi Dermatology Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyomitsu","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Yamanaka Skincare Clinic Hokkaido Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomotaka","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University Chiba Medical Center Chiba Japan"},{"name":"Department of Dermatology Kitasato University Kitasato Institute Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunao","family":"Oh\u2010i","sequence":"additional","affiliation":[{"name":"Atago Dermatology Clinic Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Kasai","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kitasato University Kitasato Institute Hospital Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryoji","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Hattori","sequence":"additional","affiliation":[{"name":"Naoko Dermatology Clinic Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryuji","family":"Maruyama","sequence":"additional","affiliation":[{"name":"Maruyama Dermatology Clinic Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuya","family":"Omi","sequence":"additional","affiliation":[{"name":"Queen's Square Medical Center Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harunari","family":"Shimoyama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University Mizonokuchi Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Sei","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University Mizonokuchi Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Nakasu","sequence":"additional","affiliation":[{"name":"Nemunoki Dermatology Clinic Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Nishimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saiseikai Kanagawa Hospital Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuki","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saiseikai Kanagawa Hospital Kanagawa Japan"},{"name":"Kanagawa Hata Dermatology Clinic Kanagawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3793-980X","authenticated-orcid":false,"given":"Takashi","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Dermatology Kanazawa Medical University Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Fukuzawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Ina Central Hospital Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0007-3632","authenticated-orcid":false,"given":"Mariko","family":"Seishima","sequence":"additional","affiliation":[{"name":"Department of Dermatology Gifu University Graduate School of Medicine Gifu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazumitsu","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Fujita Health University School of Medicine Aichi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ichiro","family":"Katayama","sequence":"additional","affiliation":[{"name":"Department of Dermatology Osaka University Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine of Sensory and Motor Organs Tottori University Faculty of Medicine Tottori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahisa","family":"Shindo","sequence":"additional","affiliation":[{"name":"Department of Dermatology National Hospital Organization Hamada Medical Center Shimane Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroe","family":"Kiryu","sequence":"additional","affiliation":[{"name":"Kiryu Dermatology Clinic Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Kusuhara","sequence":"additional","affiliation":[{"name":"Kusuhara Dermatology Clinic Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-2518","authenticated-orcid":false,"given":"Motoi","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Nagasaki University Hospital Nagasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Dermatology Teikyo University School of Medicine Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2009.00741.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7547\/87507315-87-11-512"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000469666"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.10.013"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2336\/nishinihonhifu.77.256"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14575"},{"issue":"11","key":"e_1_2_7_8_1","first-page":"25","article-title":"Treatment of onychomycosis with efinaconazole 10% topical solution and quality of life","volume":"7","author":"Tosti A","year":"2014","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-016-0073-9"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-4-50"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546630600965004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.109071"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04373.x"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00111-14"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159661"},{"key":"e_1_2_7_16_1","first-page":"175","article-title":"Is severity of disease a prognostic factor for cure following treatment of onychomycosis?","volume":"17","author":"Elewski BE","year":"2018","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_7_17_1","first-page":"24","article-title":"Efinaconazole topical solution, 10%, for the treatment of mild and moderate toenail onychomycosis","volume":"8","author":"Rodriguez DA","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13358"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.2310\/7750.2014.14090"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.1957.14"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05381.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2001.00044.x"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jfas.2008.12.012"},{"key":"e_1_2_7_24_1","first-page":"1","article-title":"Efficacy of combination therapy with efinaconazole 10% solution and 1064\u00a0nm Nd:YAG laser for treatment of toenail onychomycosis","author":"Bonhert K","year":"2018","journal-title":"J Cosmet Laser Ther"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14935","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.14935","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14935","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:52:00Z","timestamp":1693342320000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14935"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":23,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/1346-8138.14935"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14935","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2019-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}