{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:54:45Z","timestamp":1793148885852,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T00:00:00Z","timestamp":1559260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2015R1C1A2A01054767 and 2018R1D1A1B07044100"],"award-info":[{"award-number":["2015R1C1A2A01054767 and 2018R1D1A1B07044100"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic inflammatory skin disease known to be associated with a variety of systemic comorbidities, such as metabolic syndrome and obesity. Obesity represents a major comorbidity and has been suggested to be related to psoriasis. This nationwide population\u2010based prospective cohort study was performed to investigate the impacts of body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and waist circumference (<jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content>) on psoriasis. We used the health check\u2010up database and the study population consisted of subjects who had undergone health screening between January 2009 and December 2012. This study investigated patients newly diagnosed with psoriasis (International Classification of Disease, Tenth Revision, code L40) by dermatologists during the follow\u2010up period (5.32\u00a0years), based on claims data. The total population consisted of 22\u00a0633\u00a0536 subjects, among whom 399\u00a0461 had newly developed psoriasis. Subjects with <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> of more than 30 had a higher risk of psoriasis (hazards ratio [<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>], 1.118; 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>], 1.100\u20131.137) compared with the <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> 18.5\u201323 group. <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> showed a dose\u2010dependent association with psoriatic risk. Subjects with <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> over 105\u00a0cm showed the highest risk of psoriasis (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.305; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.261\u20131.349) compared with subjects with <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> lower than 80\/75 after adjusting for confounding factors, including <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>. The risk of psoriasis was highest in males with normal <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> and abdominal obesity (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>, 1.175; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.150\u20131.200). Our study indicates that <jats:styled-content style=\"fixed-case\">WC<\/jats:styled-content> is a specific factor affecting psoriatic risk and highlights the association between abdominal obesity and psoriasis, thus increasing awareness of the role of abdominal obesity in the pathogenesis and comorbidities of psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.14939","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T09:05:39Z","timestamp":1559293539000},"page":"695-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["Increased risk of psoriasis in subjects with abdominal obesity: A nationwide population\u2010based study"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-5202","authenticated-orcid":false,"given":"Ju Hee","family":"Han","sequence":"first","affiliation":[{"name":"Department of Dermatology Seoul St Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3671-502X","authenticated-orcid":false,"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul St Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Do","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Biostatistics College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha\u2010Na","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Family Medicine St Vincent's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul Hwan","family":"Bang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul St Mary's Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Min","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul St Mary's Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun Young","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul St Mary's Hospital College of Medicine The Catholic University of Korea Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Yoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Dermatology Seoul St Mary's Hospital College of Medicine The Catholic University of Korea Seoul 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