{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:34:31Z","timestamp":1759815271299,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cicatricial alopecia (<jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>) is a group of poorly understood mechanisms in which the destruction of hair follicles leads to permanent hair loss. Lichen planopilaris (<jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>) is a type of lymphocytic <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> and it has been known for epidermal Langerhans cells (<jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content>) to disappear in the scar of <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content>. We also found that epidermal <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> also disappeared in the scar of folliculitis decalvans (<jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>), a type of neutrophilic <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>. Of note was that epidermal <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> did not disappear in the scar of discoid lupus erythematosus, another type of lymphocytic <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>, suggesting that <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> disappearance in the scar was not always a common feature of <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content>. We found that the expression of integrin (<jats:styled-content style=\"fixed-case\">ITG<\/jats:styled-content>)\u2010\u03b1v\u03b26 in scar epidermis was significantly diminished in <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>, but not in other <jats:styled-content style=\"fixed-case\">PCA<\/jats:styled-content> and disorders accompanied with scar formation. We also found that exogenous interleukin\u20101\u03b2 and \u03b1\u2010interferon downregulated <jats:styled-content style=\"fixed-case\">ITG<\/jats:styled-content>\u2010\u03b1v\u03b26 expression in normal human epidermal keratinocytes. These data suggest that downregulation of <jats:styled-content style=\"fixed-case\">ITG<\/jats:styled-content>\u2010\u03b1v\u03b26 may be one of the causes of <jats:styled-content style=\"fixed-case\">LC<\/jats:styled-content> disappearance in the scar of <jats:styled-content style=\"fixed-case\">LPP<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FD<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.14945","type":"journal-article","created":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T09:36:44Z","timestamp":1559727404000},"page":"610-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Downregulation of integrin\u2010\u03b1v\u03b26 on keratinocytes in the scar of lichen planopilaris and folliculitis decalvans: Relevance for the disappearance of epidermal Langerhans cells"],"prefix":"10.1111","volume":"46","author":[{"given":"Manao","family":"Kinoshita","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2635-888X","authenticated-orcid":false,"given":"Youichi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinji","family":"Simada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Yamanashi Chuo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9059-4097","authenticated-orcid":false,"given":"Kazutoshi","family":"Harada","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tokyo Medical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyoshi","family":"Kawamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Yamanashi Chuo 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