{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T05:24:42Z","timestamp":1792301082417,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The skin microbiome plays important roles in the pathogenesis and development of acne. We aimed to investigate the facial skin microbiome of acne and microbiome differences related to different grades of acne. Skin swabs from nine healthy controls and 67 acne patients were collected, and the skin microbiomes were analyzed using 16S <jats:styled-content style=\"fixed-case\">rRNA<\/jats:styled-content> gene sequencing. Compared with healthy controls, acne patients harbored significantly altered skin microbiomes. The skin microbiomes of patients with grade 1\u20133 acne were similar, but patients with grade 4 acne showed a significantly different skin microbiome compared with grade 1\u20133 acne, including increased alpha diversity and increased proportions of four Gram\u2010negative bacteria (<jats:italic>Faecalibacterium<\/jats:italic>,<jats:italic> Klebsiella<\/jats:italic>,<jats:italic> Odoribacter<\/jats:italic> and <jats:italic>Bacteroides<\/jats:italic>). In conclusion, acne patients harbored an altered skin microbiome, and more significant dysbiosis was found in patients with grade 4 acne (severe acne). Our findings may provide evidence for the pathogenic mechanisms of acne and microbial\u2010based strategies to avoid and treat acne, especially grade 4 acne.<\/jats:p>","DOI":"10.1111\/1346-8138.14952","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T09:21:45Z","timestamp":1562750505000},"page":"787-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Skin microbiome differences relate to the grade of acne vulgaris"],"prefix":"10.1111","volume":"46","author":[{"given":"Chun\u2010xi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine Chronic Airways Diseases Laboratory Nanfang Hospital Southern Medical University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi\u2010xuan","family":"You","sequence":"additional","affiliation":[{"name":"Zhixin High School Guangzhou 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