{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:34:57Z","timestamp":1788838497235,"version":"build-2803163510"},"reference-count":6,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T00:00:00Z","timestamp":1560729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 61\u2010year\u2010old Japanese man had a gradually growing, red\u2010colored nodule in his umbilicus from 3\u00a0years ago. He had no symptoms such as hot flush, diarrhea or wheezing. Computed tomography detected a 3.0\u00a0cm\u00a0\u00d7\u00a03.0\u00a0cm enhanced nodule on the umbilical portion, inguinal and axillary lymph node swelling, and peritoneal nodules. Upper and lower gastrointestinal endoscopy and cystoscopy did not show any other tumor. We resected the umbilical nodule and subjected the inguinal lymph node and peritoneal nodule to biopsy. Histopathological findings indicated that the cutaneous lesion was composed of variously sized nests that included small, monomorphic, round to polygonal cells, mainly in the dermis to the peritoneum. Mitotic figures were scant. The inguinal lymph node and peritoneal nodule were positive for metastasis. Immunohistochemistry was diffusely positive for cytokeratin (CK)\u20107, <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>56, chromogranin A, synaptophysin, estrogen receptor\u2010\u03b1, progesterone receptor, <jats:styled-content style=\"fixed-case\">GATA<\/jats:styled-content>3 and carcinoembryonic antigen, and focally positive for mammaglobin and gross cystic disease fluid protein 15. The Ki\u201067 labeling index was 1.5%. The patient was diagnosed with a case of low\u2010grade neuroendocrine carcinoma of the skin (<jats:styled-content style=\"fixed-case\">LGNECS<\/jats:styled-content>) occurring on the umbilicus. This case exhibited distant peritoneal metastasis, as well as inguinal and axillary lymph node metastases; however, the patient is alive without chemotherapy at 23\u00a0months after the first visit. <jats:styled-content style=\"fixed-case\">LGNECS<\/jats:styled-content> is a newly proposed, extremely rare entity that has been reported under various names, including primary cutaneous carcinoid tumor. In the present case, this tumor shows a slow\u2010growing nature and favorable prognosis, even though it harbors metastatic potential.<\/jats:p>","DOI":"10.1111\/1346-8138.14985","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T15:52:19Z","timestamp":1560786739000},"page":"720-723","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Case of low\u2010grade neuroendocrine carcinoma of the skin presenting metastases to lymph nodes and peritoneum"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9978-441X","authenticated-orcid":false,"given":"Aya","family":"Okabayashi","sequence":"first","affiliation":[{"name":"Department of Dermatology Saiseikai Tondabayashi Hospital Tondabayashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8909-0713","authenticated-orcid":false,"given":"Koichi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saiseikai Tondabayashi Hospital Tondabayashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nami","family":"Shimizu","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saiseikai Tondabayashi Hospital Tondabayashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rie","family":"Tohda\u2010Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Dermatology Saiseikai Tondabayashi Hospital Tondabayashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Cancer and Infectious Disease Center Komagome Hospital Tokyo Japan"},{"name":"Department of Pathology Itabashi Central Clinical Laboratory Tokyo Japan"},{"name":"Department of Diagnostic Pathology Shizuoka Cancer Center Hospital Nagaizumi Japan"},{"name":"Department of Diagnostic Pathology and Cytology Osaka International Cancer Institute Osaka Japan"},{"name":"Department of Dermatology Hyogo Cancer Center Akashi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,17]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"425","article-title":"Karzinoide tumoren des d\u00fcnndarms","volume":"1","author":"Oberndorfer S","year":"1907","journal-title":"Frankf Z Pathol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197509)36:3<1016::AID-CNCR2820360326>3.0.CO;2-L"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0000000000000657"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.13028"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.23736\/S0392-0488.17.05085-4"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0007-1226(03)00210-8"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.14985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14985","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.14985","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.14985","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T20:53:26Z","timestamp":1693342406000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.14985"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,17]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1111\/1346-8138.14985"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.14985","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,17]]},"assertion":[{"value":"2019-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-23","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}