{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:47:34Z","timestamp":1792511254004,"version":"4.5.0"},"reference-count":21,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,6,28]],"date-time":"2019-06-28T00:00:00Z","timestamp":1561680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Staphylococcus epidermidis<\/jats:italic> is a bacterium known to inhabit the skin. In treatment of acne vulgaris, the cutaneous milieu is exposed to oral or topical antimicrobials. We previously reported that the antimicrobial resistance of <jats:italic>Cutibacterium acnes<\/jats:italic> isolated from acne patients is affected by antimicrobial use. The aim of this study was to investigate the relationship between quinolone use and resistance in skin bacteria, particularly <jats:italic>S.\u00a0epidermidis<\/jats:italic>, from acne patients. A total of 92 and 87 <jats:italic>S.\u00a0epidermidis<\/jats:italic> strains isolated from clinic patients and hospital outpatients with acne vulgaris, respectively, were tested. No significant difference was found between the prevalence of methicillin\u2010resistant <jats:italic>S.\u00a0epidermidis<\/jats:italic> (MRSE) strains from clinic patients (37.0%) and hospital outpatients (39.1%). The MRSE strains (20.6%, 14\/68 strains) showed a significantly higher ratio of high\u2010level levofloxacin resistance (minimum inhibitory concentrations were 64 to \u2265256\u00a0\u03bcg\/mL) compared with methicillin\u2010susceptible <jats:italic>S.\u00a0epidermidis<\/jats:italic> strains (2.7%, 3\/111 strains) (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). The rate of levofloxacin resistance in <jats:italic>C.\u00a0acnes<\/jats:italic> strains, which were isolated from the same samples of acne patients, showed a strong positive correlation with that in <jats:italic>S.\u00a0epidermidis<\/jats:italic> strains (<jats:italic>r\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.93, <jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). The high\u2010level levofloxacin\u2010resistant strains were frequently found in patients with history of quinolone use compared with those without (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.01). Our data showed for the first time that antimicrobial administration for acne treatment affects the antimicrobial resistance in not only <jats:italic>C.\u00a0acnes<\/jats:italic> but also <jats:italic>S.\u00a0epidermidis<\/jats:italic>. Thus, caution should be exercised in antimicrobial use for acne treatment to prevent increasing antimicrobial resistance in these species.<\/jats:p>","DOI":"10.1111\/1346-8138.15000","type":"journal-article","created":{"date-parts":[[2019,6,29]],"date-time":"2019-06-29T01:29:47Z","timestamp":1561771787000},"page":"782-786","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Relationship between quinolone use and resistance of <i>Staphylococcus epidermidis<\/i> in patients with acne vulgaris"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-3008","authenticated-orcid":false,"given":"Keisuke","family":"Nakase","sequence":"first","affiliation":[{"name":"Department of Microbiology School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hikaru","family":"Saita","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1971-230X","authenticated-orcid":false,"given":"Nobukazu","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology Toranomon Hospital Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setsuko","family":"Nishijima","sequence":"additional","affiliation":[{"name":"Nishijima Skin Clinic Neyagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2889-8257","authenticated-orcid":false,"given":"Hidemasa","family":"Nakaminami","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4710-7297","authenticated-orcid":false,"given":"Norihisa","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Microbiology School of Pharmacy Tokyo University of Pharmacy and Life Sciences Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,6,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2182"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01401"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-018-0362-9"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-597"},{"issue":"7","key":"e_1_2_7_6_1","first-page":"DC27","article-title":"Distribution of SCCmec elements and presence of panton\u2010valentine leukocidin in methicillin\u2010resistant Staphylococcus epidermidis isolated from clinical samples in a university hospital of Isfahan city, Iran","volume":"11","author":"Halaji M","year":"2017","journal-title":"J Clin Diagn Res"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-013-0440-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14355"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13913"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.7.2637-2651.2004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00488-11"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01720.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.2008\/002824-0"},{"key":"e_1_2_7_14_1","unstructured":"CLSI. 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