{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T04:05:14Z","timestamp":1792555514790,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T00:00:00Z","timestamp":1564704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperhidrosis can seriously impair patients\u2019 quality of life. Medical history, including heredity and hyperhidrosis during youth, as well as current age and time elapsed since menopause, is important to consider when distinguishing between postmenopausal hyperhidrosis and vasomotor symptoms to enable adequate treatment. This report concerns a subgroup of eight postmenopausal patients participating in a randomized controlled trial regarding botulinum toxin (Btx) type B treatment in craniofacial hyperhidrosis. Even though the sample size is small and the enrolment is not yet completed, the promising data collected hitherto are interesting to present in advance because this subtype of craniofacial hyperhidrosis is often underrecognized and challenging to treat. Patients were randomized to receive Btx type B or placebo. Measurements were performed before treatment and 3\u00a0\u00b1\u00a01\u00a0weeks after. The Dermatology Life Quality Index (<jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content>) score was improved for all patients after Btx type B treatment (<jats:italic>n<\/jats:italic>\u00a0=\u00a03) with a median decrease of 9\u00a0points (90% median improvement). The placebo group (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) had a median increase of 2\u00a0points (\u201318% median decline). When the same group (<jats:italic>n<\/jats:italic>\u00a0=\u00a05) received Btx type B (open) the <jats:styled-content style=\"fixed-case\">DLQI<\/jats:styled-content> score decreased with a median of 7\u00a0points compared with baseline (91% median improvement). Treatment\u2010related adverse events were temporary and did not prevent improvement of life quality. Furthermore, background data evaluation uncovered interesting findings regarding vasomotor symptoms in relation to postmenopausal hyperhidrosis. In conclusion, the results indicated that Btx type B seems to be a safe and effective treatment in postmenopausal craniofacial hyperhidrosis. Further research is encouraged.<\/jats:p>","DOI":"10.1111\/1346-8138.15029","type":"journal-article","created":{"date-parts":[[2019,8,2]],"date-time":"2019-08-02T12:24:32Z","timestamp":1564748672000},"page":"874-878","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Postmenopausal craniofacial hyperhidrosis treated with botulinum toxin type B"],"prefix":"10.1111","volume":"46","author":[{"given":"Philip","family":"Cabreus","sequence":"first","affiliation":[{"name":"Hidrosis Clinic Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl","family":"Swartling","sequence":"additional","affiliation":[{"name":"Hidrosis Clinic Stockholm Sweden"},{"name":"Department of Medical Sciences, Dermatology and Venereology Uppsala University Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7435-1327","authenticated-orcid":false,"given":"Alma","family":"Rystedt","sequence":"additional","affiliation":[{"name":"Hidrosis Clinic Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,2]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(97)00014-3"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-4362.1999.00609.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1697-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.29245\/2572.942X\/2016\/4.1037"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590802632514"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2018.06.460"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5122(88)90022-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12278"},{"key":"e_1_2_6_10_1","unstructured":"International Hyperhidrosis Society.Primary Craniofacial Hyperhidrosis. 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