{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:14:59Z","timestamp":1783350899513,"version":"3.54.6"},"reference-count":24,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with dermatomyositis positive for anti\u2010aminoacyl tRNA synthetase (ARS) antibodies, also known as antisynthetase syndrome (ASS), frequently present with mechanic's hand and interstitial lung disease (ILD). We first screened the antibody profiles of 59 patients with dermatomyositis, and then examined the cutaneous, muscular and pulmonary manifestations characteristic for patients with ASS. The anti\u2010ARS antibodies Jo\u20101, PL\u20107, PL\u201012, EJ and KS, along with antibodies to TIF1\u2010\u03b3, MDA5 and Mi\u20102, were examined. Among the 59 patients, 20, 21, 15 and three patients were classified into the ASS, non\u2010ASS, myositis\u2010specific antibody\u2010negative and unknown groups, respectively. Five of 16 patients (31%) with ASS had six relatives with a history of collagen diseases, within the second degree of relationship, including two cases of dermatomyositis (vs the non\u2010ASS group, <jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0.018). Patients with ASS more frequently presented with fever and arthralgia, and had elevated levels of C\u2010reactive protein. Nine of the 11 finger lesions (82%) clinically diagnosed as mechanic's hands showed a psoriasiform tissue reaction. ILD was observed in 19 of 20 patients (95%) with ASS, and eight of 21 patients (38%) in the non\u2010ASS group, in which six patients possessed anti\u2010MDA5 antibody. Patients with ASS showed higher serum levels of muscle enzymes, and four of 12 patients (33%) had fasciitis\u2010dominant myopathy, while only one of 11 patients (9%) in the non\u2010ASS group had fasciitis\u2010dominant myopathy. Patients with ASS often present with a psoriasiform tissue reaction in the hand lesions and fasciitis\u2010dominant myopathy, and the relatives of those with ASS are at high risk for collagen diseases.<\/jats:p>","DOI":"10.1111\/1346-8138.15049","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T12:27:55Z","timestamp":1565958475000},"page":"886-897","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Clinical manifestations of skin, lung and muscle diseases in dermatomyositis positive for anti\u2010aminoacyl tRNA synthetase antibodies"],"prefix":"10.1111","volume":"46","author":[{"given":"Hiroko","family":"Fukamatsu","sequence":"first","affiliation":[{"name":"Department of Dermatology Dentistry, and Pharmaceutical Sciences Okayama University Graduate School of Medicine Okayama 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