{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T01:40:21Z","timestamp":1782351621170,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Interstitial lung disease (<jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content>) is a rare complication of Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis (<jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>). In this study, we present the case of a 33\u2010year\u2010old woman who was diagnosed with <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> related to <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content> overlap syndrome. Surprisingly, the patient did not respond to combination therapy with steroids and i.v. immunoglobulin, but rapidly improved after two doses of etanercept treatment. To our knowledge, this is the first case of <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>\u2010induced <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> that was successfully treated with etanercept. We reviewed another two cases of <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> associated with <jats:styled-content style=\"fixed-case\">SJS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">TEN<\/jats:styled-content>, and found that unlike the other cases, in the present case, <jats:styled-content style=\"fixed-case\">ILD<\/jats:styled-content> occurred early in the course of the disease and rapidly improved after etanercept injection. We discovered that in the present patient, the serum interleukin\u20106 level increased during the progressive stage and declined after the initiation of treatment with etanercept.<\/jats:p>","DOI":"10.1111\/1346-8138.15058","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T09:48:01Z","timestamp":1566467281000},"page":"1035-1038","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Successful treatment of interstitial lung disease related to Stevens\u2013Johnson syndrome\/toxic epidermal necrolysis overlap with etanercept: A case report and published work review"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3327-4177","authenticated-orcid":false,"given":"Fang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital Sun Yat\u2010sen University Guangzhou 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