{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:33:42Z","timestamp":1777664022456,"version":"3.51.4"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2E29290"],"award-info":[{"award-number":["2E29290"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hair follicles are among the most highly proliferative tissues. Polyamines are associated with proliferation, and several polyamines including spermidine and spermine play anti\u2010inflammatory roles. Androgenic alopecia results from increased dihydrotestosterone metabolism, and alopecia areata is an autoimmune disease. This study aimed to investigate differences in polyamine profiles in hair samples between patients with androgenic alopecia and alopecia areata. Polyamine concentrations were determined through high\u2010performance liquid chromatography\u2010mass spectrometry. Hair samples were derivatized with isobutyl chloroformate. Differences in polyamine levels were observed between androgenic alopecia and alopecia areata compared with normal controls. In particular, polyamine levels were higher in alopecia areata patients than in normal controls. Certain polyamines displayed different concentrations between the androgenic alopecia and alopecia areata groups, suggesting that some polyamines, particularly N\u2010acetyl putrescine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.007) and N\u2010acetyl cadaverine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.0021), are significantly different in androgenic alopecia. Furthermore, spermidine (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.021) was significantly different in alopecia areata. Our findings suggest that non\u2010invasive quantification of hair polyamines may help distinguish between androgenic alopecia and alopecia areata. Our study provides novel insights into physiological alterations in patients with androgenic alopecia and those with alopecia areata and reveals some differences in polyamine levels in hair loss diseases with two different modes of action.<\/jats:p>","DOI":"10.1111\/1346-8138.15063","type":"journal-article","created":{"date-parts":[[2019,8,29]],"date-time":"2019-08-29T05:05:07Z","timestamp":1567055107000},"page":"985-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Altered polyamine profiling in the hair of patients with androgenic alopecia and alopecia areata"],"prefix":"10.1111","volume":"46","author":[{"given":"Yu Ra","family":"Lee","sequence":"first","affiliation":[{"name":"Molecular Recognition Research Center Korea Institute of Science and Technology Seoul Korea"},{"name":"KHU\u2010KIST Department of Converging Science and Technology Kyung Hee University Seoul 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Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4449-0043","authenticated-orcid":false,"given":"Bong Chul","family":"Chung","sequence":"additional","affiliation":[{"name":"Molecular Recognition Research Center Korea Institute of Science and Technology Seoul Korea"},{"name":"KHU\u2010KIST Department of Converging Science and Technology Kyung Hee University Seoul 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