{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T15:28:59Z","timestamp":1781537339925,"version":"3.54.5"},"reference-count":15,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:00:00Z","timestamp":1566432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Medical Guidance Project of Shanghai Science and Technology Commission"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The correlation between polymorphisms at the tumor necrosis factor (<jats:italic>TNF<\/jats:italic>) gene and generalized pustular psoriasis (GPP) has rarely been reported. The goal of this study is to investigate whether <jats:italic>TNF<\/jats:italic> polymorphisms (\u2212238 A\/G, \u2212308 A\/G, \u2212857C\/T) are associated with susceptibility to GPP in a Han population from Eastern China and to perform subgroup analysis to explore the influence of age onset. Polymorphisms were assessed by polymerase chain reaction amplification and resequencing in 91 GPP patients and 102 healthy controls. The frequencies of the <jats:italic>TNF<\/jats:italic> \u2212238A allele and GA+AA genotypes were significantly higher in GPP patients than in those of healthy controls. The subgroup analysis revealed that these significant associations were still present between \u2212238A variants and pediatric\u2010onset GPP patients who developed GPP at less than 18\u00a0years old (PGPP), but not for patients with adult\u2010onset GPP who developed GPP at 18\u00a0years old or more. There were no significant differences in genotype or allele frequencies of <jats:italic>TNF<\/jats:italic> \u2212308 A\/G and \u2212857C\/T polymorphisms between GPP and controls. In conclusion, individuals carrying <jats:italic>TNF<\/jats:italic> \u2212238A may be more susceptible to PGPP.<\/jats:p>","DOI":"10.1111\/1346-8138.15066","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T10:55:21Z","timestamp":1566471321000},"page":"1031-1034","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Tumor necrosis factor \u2013238A is associated with pediatric\u2010onset generalized pustular psoriasis in Han patients in Eastern China"],"prefix":"10.1111","volume":"46","author":[{"given":"Lishi","family":"Zhao","sequence":"first","affiliation":[{"name":"STD Institute Shanghai Dermatology Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Life Sciences Shaanxi Normal University Xi'an 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