{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:20:49Z","timestamp":1747182049770,"version":"3.40.5"},"reference-count":21,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Post\u2010herpetic neuralgia (<jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>) is a well\u2010established clinical problem with potential severe personal and socioeconomic implications. <jats:styled-content style=\"fixed-case\">GTP<\/jats:styled-content> cyclohydrolase 1 (<jats:italic><jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content>1<\/jats:italic>) gene, which encodes the rate\u2010limiting enzyme in tetrahydrobiopterin synthesis, has been strongly implicated to be associated with neuropathic pain in previous animal and human studies. The rs3783641 (T\u00a0&gt;\u00a0A) single\u2010nucleotide polymorphism (<jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content>) in the <jats:italic><jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content>1<\/jats:italic> gene is functional. Here we examine the association between rs3783641 and <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>. A total of 292 subjects including 103 <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> patients, 87 herpes zoster (<jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content>) patients and 102 healthy controls were enrolled in this study. The rs3783641 polymorphisms were detected via the high\u2010resolution melting curve (<jats:styled-content style=\"fixed-case\">HRM<\/jats:styled-content>) method. There were statistical differences between <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> group and the other two groups in genotype distribution (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.029 and 0.017, respectively) and allele frequency (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.032 and 0.005, respectively) of rs3783641. The proportion of subjects with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype in the <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> group was significantly lower compared to <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> group and control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.026 and 0.016, respectively). The frequency of A allele was lower in the <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> group than in control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.005), and the frequency of T allele in the <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content> group was higher than in <jats:styled-content style=\"fixed-case\">HZ<\/jats:styled-content> group and control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001 and 0.003, respectively). The results of this study suggest that the rs3783641 <jats:styled-content style=\"fixed-case\">SNP<\/jats:styled-content> in the <jats:italic><jats:styled-content style=\"fixed-case\">GCH<\/jats:styled-content>1<\/jats:italic> gene is associated with <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>, and the <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> genotype showed a protective effect in <jats:styled-content style=\"fixed-case\">PHN<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.15067","type":"journal-article","created":{"date-parts":[[2019,9,5]],"date-time":"2019-09-05T04:23:22Z","timestamp":1567657402000},"page":"993-997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association of rs3783641 single\u2010nucleotide polymorphism in <scp>GTP<\/scp> cyclohydrolase 1 gene with post\u2010herpetic neuralgia"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8905-2346","authenticated-orcid":false,"given":"Na\u2010Na","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9977-3518","authenticated-orcid":false,"given":"Ruo\u2010Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3304-0562","authenticated-orcid":false,"given":"Xiao\u2010Xiao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8642-4653","authenticated-orcid":false,"given":"Lian\u2010Sheng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Affiliated Hospital of Xuzhou Medical University Xuzhou 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