{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,24]],"date-time":"2025-05-24T05:05:24Z","timestamp":1748063124929,"version":"3.40.5"},"reference-count":24,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"Abstract<\/jats:title>Cell adhesion molecule 1 (CADM<\/jats:styled-content>1) is aberrantly expressed by T\u2010cell neoplasms such as adult T\u2010cell leukemia\/lymphoma (ATLL<\/jats:styled-content>) and mycosis fungoides (MF<\/jats:styled-content>). We studied the expression of CADM<\/jats:styled-content>1 and its splicing variants in S\u00e9zary syndrome (SS<\/jats:styled-content>), MF<\/jats:styled-content>, other cutaneous T\u2010cell lymphoma (CTCL<\/jats:styled-content>), and cell lines derived from T\u2010 and B\u2010cell lymphomas. Soluble CADM<\/jats:styled-content>1 was measured in the patients\u2019 sera. CADM<\/jats:styled-content>1+ cells in the blood and skin lesions were examined by flow cytometry and immunostaining, respectively. Soluble CADM<\/jats:styled-content>1 was measured by ELISA<\/jats:styled-content>, and the splicing variants of CADM<\/jats:styled-content>1<\/jats:italic> transcripts were determined by reverse transcriptase\u2010polymerase chain reaction, followed by sequencing. As a result, circulating CADM<\/jats:styled-content>1+ cells were significantly increased in seven out of 10 patients with SS<\/jats:styled-content>, ranging from 7.9% to 74.5% of the CD<\/jats:styled-content>3+CD<\/jats:styled-content>4+ fractions (median 33.7%; cut\u2010off value 6.5%). The percentages of CADM<\/jats:styled-content>1+ cells were usually less than those of circulating S\u00e9zary cells. CADM<\/jats:styled-content>1 was expressed, to various degrees, in six of nine T\u2010cell lines derived from SS<\/jats:styled-content>, MF<\/jats:styled-content>, ATLL<\/jats:styled-content>, and anaplastic large cell lymphoma (ALCL<\/jats:styled-content>), but negative in B\u2010cell lymphoma\u2010derived cell lines. CADM<\/jats:styled-content>1+ cells were present in the skin infiltrates of MF<\/jats:styled-content>, SS<\/jats:styled-content>, ATLL<\/jats:styled-content> and ALCL<\/jats:styled-content>. Serum levels of soluble CADM<\/jats:styled-content>1 were not significantly elevated in SS<\/jats:styled-content>\/MF<\/jats:styled-content>. Three major splicing variants of CADM<\/jats:styled-content>1 expressed by neoplastic T\u2010cells contained different combinations of the exons 7, 8, 9 and 11, including a putative oncogenic variant composed of exons 7\u20108\u20109\u201011. In conclusion, CADM<\/jats:styled-content>1 is frequently expressed in S\u00e9zary cells and cell lines from CTCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/1346-8138.15078","type":"journal-article","created":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T06:31:01Z","timestamp":1568356261000},"page":"967-977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The expression of cell adhesion molecule 1 and its splicing variants in S\u00e9zary cells and cell lines from cutaneous T\u2010cell lymphoma"],"prefix":"10.1111","volume":"46","author":[{"given":"Mari","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Dermatology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama 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