{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T12:29:45Z","timestamp":1780921785987,"version":"3.54.1"},"reference-count":91,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Palmoplantar pustulosis (PPP) is characterized by symmetrical, erythematous, scaly plaques, with numerous, sterile, non\u2010bacterial, pinpoint pustules, which are restricted to the palms and soles. Because several reports have described the efficacy of tonsillectomy for improvement in PPP skin lesions, we consider that PPP is tonsil\u2010induced autoimmune\/inflammatory syndrome (TIAS) while other factors are also involved in the pathogenesis of PPP. Here, the association between PPP pathogenesis and TIAS was examined, with a focus on results of previous studies. PPP patients show a hyperimmune response to indigenous bacteria such as \u03b1\u2010streptococci, due to impaired immunological tolerance towards such organisms. Such a novel immune response leads to T\u2010cell activation through the abnormal expression of secondary stimulation molecules, including cytotoxic T\u2010lymphocyte\u2010associated antigen 4, inducible T\u2010cell co\u2010stimulator and Smad7, in the tonsils of PPP patients. Activated tonsillar T cells express cutaneous lymphocyte antigen (CLA), CCR6 and \u03b21\u2010integrin, enter the blood circulation and are recruited to PPP skin lesions. Within lesions, T cells roll onto endothelial cells through the interaction between CLA and E\u2010selectin, migrate into the extravascular area through \u03b21\u2010integrin\u2013vascular cell adhesion molecule 1 binding, and assemble in the skin through CCL20\u2013CCR6 binding. Hyperimmune responses to autoantigens such as keratin and heat shock proteins could also be involved in PPP pathogenesis, through the stimulation of the T\u2010helper 17 reaction.<\/jats:p>","DOI":"10.1111\/1346-8138.15100","type":"journal-article","created":{"date-parts":[[2019,9,26]],"date-time":"2019-09-26T00:44:05Z","timestamp":1569458645000},"page":"931-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Pathogenic role of palatine tonsils in palmoplantar pustulosis: A review"],"prefix":"10.1111","volume":"46","author":[{"given":"Yasuaki","family":"Harabuchi","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0535-5778","authenticated-orcid":false,"given":"Miki","family":"Takahara","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Asahikawa Medical University Asahikawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1934.01460100066006"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1974.01630040028005"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309121151"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2003.12094.x"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2004.23556.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546631003636817"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-018-00745-6"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14348"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2001.27690"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfu020"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-015-1138-7"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102834"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/09546634.2013.848258"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2014-206899"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.5414\/CNP67298"},{"key":"e_1_2_12_17_1","first-page":"206","article-title":"Reactive arthritis induced by tonsillitis","volume":"523","author":"Kobayashi S","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2009.06.005"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324583"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1935.01470060002001"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.1977.tb01033.x"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309121154"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309121152"},{"key":"e_1_2_12_24_1","first-page":"161","article-title":"Clinical analyses of focus tonsil and related diseases in Japan","volume":"523","author":"Kataura A","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_12_25_1","first-page":"2319","article-title":"Clinical effect of tonsillectomy in patients with Pustulosis Palmaris et Plantaris (PPP)","volume":"114","author":"Yamakita T","year":"2004","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_12_26_1","first-page":"49","article-title":"Clinical effect of tonsillectomy in patients with Pustulosis Palmaris et Plantaris (PPP)","volume":"22","author":"Yamakita T","year":"2009","journal-title":"Stomato\u2010pharyngology"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000324618"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-2-192"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.40.6.547"},{"key":"e_1_2_12_30_1","first-page":"187","article-title":"Acne\u2010pustulosis\u2010hyperostosis\u2010osteitis syndrome. Results of a national survey. 85 cases","volume":"54","author":"Chamot AM","year":"1987","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200201000-00017"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.20971"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.23270"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2018.10.008"},{"key":"e_1_2_12_35_1","first-page":"71","article-title":"Risk factors of and countermeasure against post\u2010tonsillectomy hemorrhage","volume":"29","author":"Ikoma R","year":"2016","journal-title":"Stomato\u2010pharyngology"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-014-3312-z"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.147.21"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309132738"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.92.1958"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.93.1869"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309132890"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/00016489950181431"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.102.265"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.102.254"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(89)90137-3"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.63.3.853-857.1995"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2007.11.003"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.93.949"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.93.786"},{"key":"e_1_2_12_50_1","first-page":"201","article-title":"Cytokine production by tonsillar lymphocytes stimulated with alpha\u2010streptococci in patients with pustulosis palmaris et plantaris","volume":"523","author":"Murakata H","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.01.001"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489309130264"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1994.tb02591.x"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-010-9451-0"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.12.010"},{"key":"e_1_2_12_56_1","first-page":"193","article-title":"Animal model of focal tonsillar infection: human tonsillar lymphocytes induce skin lesion in SCID mice","volume":"523","author":"Hayashi Y","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1348-0421.2001.tb02651.x"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2005.01.009"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03945.x"},{"key":"e_1_2_12_60_1","first-page":"1053","article-title":"A unique phenotype of skin\u2010associated lymphocytes in humans. Preferential expression of the HECA\u2010452 epitope by benign and malignant T cells at cutaneous sites","volume":"136","author":"Picker LJ","year":"1990","journal-title":"Am J Pathol"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.12.6621"},{"key":"e_1_2_12_62_1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.4049\/jimmunol.144.4.1233","article-title":"Ability of human T lymphocytes to adhere to vascular endothelial cells and to augment endothelial permeability to macromolecules is linked to their state of post\u2010thymic maturation","volume":"144","author":"Damle NK","year":"1990","journal-title":"J Immunol"},{"key":"e_1_2_12_63_1","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.4049\/jimmunol.154.4.1543","article-title":"Migration of skin\u2010homing T cells across cytokine\u2010activated human endothelial cell layers involves interaction of the cutaneous lymphocyte\u2010associated antigen (CLA), the very late antigen\u20104 (VLA\u20104), and the lymphocyte function\u2010associated antigen\u20101 (LFA\u20101)","volume":"154","author":"Santamaria Babi LF","year":"1995","journal-title":"J Immunol"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2011.01325.x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.181.7.4733"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.5937"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.01.066"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309121153"},{"key":"e_1_2_12_69_1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2340\/00015555-0217","article-title":"Sera from patients with palmoplantar pustulosis show immunoreactivity against endothelial cells","volume":"87","author":"Hagforsen E","year":"2007","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_12_70_1","first-page":"301","article-title":"Anti\u2010keratin layer antibody on Pustulosis palmaris et plantaris","volume":"43","author":"Okamoto H","year":"1980","journal-title":"Nishinihon J Dermatol"},{"key":"e_1_2_12_71_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2340\/0001555553123126","article-title":"Immunofluorescence studies in pustulosis palmoplantaris","volume":"53","author":"Husby G","year":"1973","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1970.tb15075.x"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488809125033"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00457465"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309121160"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489.2013.831477"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.3950\/jibiinkoka.102.226"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1991.tb14769.x"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2004.00600.x"},{"key":"e_1_2_12_80_1","first-page":"197","article-title":"Antibody production to heat shock proteins with Mr 65 kD (HSP65) in cutaneous inflammation: a possible relation to focal infection","volume":"523","author":"Izaki S","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-302x.2000.150404.x"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.59.4.1434-1441.1991"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.56.6.1633-1640.1988"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anl.2008.11.009"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.12.002"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2479"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309121156"},{"key":"e_1_2_12_88_1","first-page":"20","article-title":"Immunohistological studies on tonsils with recurrent tonsillitis and focus\u2010tonsil with pustulosis palmaris et plantaris","volume":"416","author":"Kuki K","year":"1984","journal-title":"Acta Otolaryngol"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009122574"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.2266"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05505"},{"key":"e_1_2_12_92_1","first-page":"213","article-title":"Evaluation of the provocation test of tonsils: a report from the Committee for the standardization of diagnostic criteria for tonsillar focal infections","volume":"9","author":"Kataura A","year":"1997","journal-title":"Stomato\u2010pharyngology"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15100","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15100","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T18:31:54Z","timestamp":1694025114000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":91,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1111\/1346-8138.15100"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15100","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.736672129.793586744","asserted-by":"object"}]},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]},"assertion":[{"value":"2019-04-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}