{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T14:08:35Z","timestamp":1772806115547,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T00:00:00Z","timestamp":1570579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The emergence of bacterial resistance is a global crisis. Prolonged use of antibiotics especially in acne is one issue of concern among dermatologists. Ketoconazole (KTZ) cream, a topical antifungal with anti\u2010inflammatory and antiandrogenic actions, can decrease lipase activity of<jats:italic>Cutibacterium acnes in vitro<\/jats:italic>. We evaluated the efficacy and safety of KTZ cream in mild adult female acne (AFA) by conducting a randomized, double\u2010blind, placebo\u2010controlled trial using KTZ 2% and placebo cream twice daily for 10\u00a0weeks. We assessed the improvement of clinical severity, measured by AFA score graded by investigators and participants, and the change of acne count. Forty\u2010one participants enrolled in our study. The proportion of participants with acne improvement from baseline (42.9% vs 9.5%,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.015) and the success rate (45.0% vs 14.3%,<jats:italic>P<\/jats:italic>\u00a0=\u00a00.043) in the KTZ group were significantly higher than that of the placebo group. The most common adverse events were dryness and itching. The percentage change of acne count decreased significantly compared with baseline but did not differ statistically between the two groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.268). We concluded that the KTZ monotherapy showed a plausible effect in improving AFA with excellent safety profile. It should be considered as a viable option for mild AFA treatment.<\/jats:p>","DOI":"10.1111\/1346-8138.15113","type":"journal-article","created":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T04:04:55Z","timestamp":1570680295000},"page":"1184-1189","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Topical 2% ketoconazole cream monotherapy significantly improves adult female acne: A double\u2010blind, randomized placebo\u2010controlled trial"],"prefix":"10.1111","volume":"46","author":[{"given":"Natcha","family":"Chottawornsak","sequence":"first","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"The Thai Red Cross Society of Thailand King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuda","family":"Chongpison","sequence":"additional","affiliation":[{"name":"Research Affairs Center for Excellence in Biostatistics Faculty of Medicine Chulalongkorn University Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravit","family":"Asawanonda","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"The Thai Red Cross Society of Thailand King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8975-0523","authenticated-orcid":false,"given":"Chanat","family":"Kumtornrut","sequence":"additional","affiliation":[{"name":"Division of Dermatology Department of Medicine Faculty of Medicine Chulalongkorn University Bangkok Thailand"},{"name":"The Thai Red Cross Society of Thailand King Chulalongkorn Memorial Hospital Bangkok Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,10,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2018.05.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00527-7"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09546634.2019.1623372"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14355"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15843"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.09.078"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.12993"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13245"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000356777"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70442-6"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20198203"},{"issue":"2","key":"e_1_2_7_13_1","first-page":"257","article-title":"The antiinflammatory effects of ketoconazole. 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