{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T08:09:34Z","timestamp":1769328574133,"version":"3.49.0"},"reference-count":39,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with dermatomyositis (DM) frequently have myositis\u2010specific autoantibodies (MSA), which are closely associated with different clinical features. Patients with anti\u2010aminoacyl\u2010tRNA synthetase antibody (ARS\u2010Ab) and anti\u2010melanoma differentiation\u2010associated gene 5 (MDA5)\u2010Ab often have interstitial lung disease (ILD). Recently, anti\u2010MDA5\u2010Ab levels have been shown to correlate with disease activity in DM patients. Thus, B cells that are stimulated by excess B\u2010cell activating factor (BAFF) play an important role in the pathogenesis of DM through auto\u2010Ab production. In this study, we investigated the role of BAFF in DM patients. We measured the serum BAFF levels in 56 adult DM patients (14 with anti\u2010ARS\u2010Ab, 18 with anti\u2010MDA5\u2010Ab, seven with anti\u2010Mi\u20102\u2010Ab and 17 with anti\u2010transcriptional intermediary factor\u20101\u03b3\u2010Ab) . For a longitudinal study, 130 serum specimens from 10 DM patients with anti\u2010MDA5\u2010Ab were analyzed. Serum BAFF levels were significantly higher in DM patients than in healthy controls. DM patients with elevated serum BAFF levels more frequently had ILD. In subgroup analysis, DM patients with anti\u2010ARS\u2010Ab and DM patients with anti\u2010MDA5\u2010Ab exhibited increased BAFF levels compared with controls, while DM patients with other MSA showed BAFF levels comparable with controls. In the longitudinal study, serum BAFF levels in DM patients with anti\u2010MDA5\u2010Ab were decreased after immunosuppressive therapy along with serum levels of anti\u2010MDA5\u2010Ab and ferritin, which are biomarkers of disease activity. These results suggest that BAFF plays an important role in the pathogenesis of ILD in DM patients with anti\u2010ARS and anti\u2010MDA5\u2010Ab. Furthermore, serum BAFF level is associated with disease activity in DM patients with anti\u2010MDA5\u2010Ab.<\/jats:p>","DOI":"10.1111\/1346-8138.15117","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T04:05:52Z","timestamp":1571630752000},"page":"1190-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Elevated serum B\u2010cell activating factor levels in patients with dermatomyositis: Association with interstitial lung disease"],"prefix":"10.1111","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-086X","authenticated-orcid":false,"given":"Takashi","family":"Matsushita","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa 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