{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:49:09Z","timestamp":1780447749366,"version":"3.54.1"},"reference-count":15,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hidradenitis suppurativa (HS) is a follicular occlusive inflammatory skin disease that occurs in the axilla, groin, buttocks and vulval region. Control of the intractable inflammation is a primary goal of HS treatments. Benefit of anti\u2010tumor necrosis factor (TNF) antibodies against HS have been reported, and adalimumab has been approved for HS in Europe, the USA and Japan. However, the alternative therapies for anti\u2010TNF antibodies have not been established yet. We experienced a case of HS which developed during the infliximab treatment for Crohn\u2019s disease (CD) and was well managed by ustekinumab (UST). We reviewed the articles relating to ustekinumab treatments for HS. Twenty\u2010four HS patients, 16 women and eight men, have been treated with ustekinumab. The average age was 35.7\u00a0\u00b1\u00a010.8\u00a0years (mean\u00a0\u00b1\u00a0SD). All were of Hurley stage II or III. Ten (10\/24, 41.6%) had received anti\u2010TNF drugs including infliximab, adalimumab and etanercept prior to UST treatment for HS. Although the initial doses varied from 45\u00a0mg s.c. to 390\u00a0mg i.v., all cases were treated with 45 or 90\u00a0mg s.c. every 8 or 12\u00a0weeks at the regular dose, by following the regimen for psoriasis or CD. HS in most of the cases started to improve after 3\u20135\u00a0months of UST initiation, and some achieved complete remission. To our knowledge, our case is the first Asian HS patient improved by UST. Overall, UST is useful for HS and could be an alternative treatment if HS patients do not respond to other medications including anti\u2010TNF drugs.<\/jats:p>","DOI":"10.1111\/1346-8138.15122","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T10:04:48Z","timestamp":1571738688000},"page":"1215-1218","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Ustekinumab treatment for hidradenitis suppurativa"],"prefix":"10.1111","volume":"46","author":[{"given":"Kana","family":"Takeda","sequence":"first","affiliation":[{"name":"Departments of Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0457-9262","authenticated-orcid":false,"given":"Katsuko","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Departments of Department of Dermatology Tohoku 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