{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T21:57:45Z","timestamp":1788904665121,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573051"],"award-info":[{"award-number":["81573051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872534"],"award-info":[{"award-number":["81872534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is a chronic, recurrent inflammatory autoimmune skin disease. Although its etiology and pathogenesis are complex and multifarious, it has been proved to be closely related to dysregulation of immune cell function as well as keratinocyte proliferation\/differentiation. Our previous study demonstrated that miRNA\u2010210 (miR\u2010210) plays an important role in the formation of skin lesions and immune imbalance in psoriasis. Here, we developed a biomimetic reconstituted high\u2010density lipoprotein (rHDL) nanocarrier gel containing miR\u2010210 antisense (NG\u2010anti\u2010miR\u2010210) to investigate its effect on imiquimod (IMQ)\u2010induced psoriasis\u2010like dermatitis in mice. We found that topical treatment with NG\u2010anti\u2010miR\u2010210 significantly decreased the expression of miR\u2010210 in both the skin lesions and splenic CD4<jats:sup>+<\/jats:sup> T cells from IMQ\u2010induced psoriasis\u2010like mouse models and ameliorated the dermatitis in terms of the erythema, scales, acanthosis and dermal inflammatory cell infiltration in IMQ\u2010induced mice. In addition, the proportion of T\u2010helper (Th)1 and Th17 cells in dermal and splenic cells of IMQ\u2010treated mice were decreased by application of NG\u2010anti\u2010miR\u2010210, accompanied by decreased interleukin\u201017A and \u03b3\u2010interferon mRNA levels. Therefore, our data demonstrate that topical inhibition of miR\u2010210 delivered by rHDL nanocarrier effectively alleviates the psoriasis\u2010like inflammation in mice and provides a potentially effective topical drug for psoriasis.<\/jats:p>","DOI":"10.1111\/1346-8138.15149","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T08:54:34Z","timestamp":1574844874000},"page":"147-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["Topical administration of nanocarrier miRNA\u2010210 antisense ameliorates imiquimod\u2010induced psoriasis\u2010like dermatitis in mice"],"prefix":"10.1111","volume":"47","author":[{"given":"Huan","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Dermatology Hunan Key Laboratory of Medical Epigenomics The Second Xiangya Hospital of Central South University Changsha China"},{"name":"Research Unit of Key Technologies of 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