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The dominance of the interleukin (IL)\u201023\/IL\u201017 axis is a significant breakthrough in the understanding of the pathogenesis of psoriasis, and treatment targeting IL\u201023 and IL\u201017 has successfully benefited patients with the disease. The skin contains a complex network of dendritic cells (DC) mainly composed of epidermal Langerhans cells, bone marrow\u2010derived dermal conventional DC, plasmacytoid DC and inflammatory DC. As the prominent cellular source of \u03b1\u2010interferon, tumor necrosis factor\u2010\u03b1, IL\u201012 and IL\u201023, DC play a pivotal role in psoriasis. Thus, targeting pathogenic DC subsets is a valid strategy for alleviating and preventing psoriasis and other DC\u2010derived diseases. 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