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To clarify the relationship between taking DPP\u20104 inhibitors and the risk of BP among patients with DM, we conducted a cohort study by using the National Health Insurance Research Database of Taiwan from 1\u00a0January 2009 to 31\u00a0December 2015. We identified 6340 patients with DM taking DPP\u20104 inhibitors and 25\u00a0360 DM patients who had not taken DPP\u20104 inhibitors during the 7\u2010year follow\u2010up period. Compared with the non\u2010DPP\u20104 inhibitor group, patients taking DDP\u20104 inhibitors had a higher risk of BP (adjusted hazard ratio [aHR], 2.382; 95% confidence interval (CI), 1.163\u20134.883; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.017]. Among the DPP\u20104 inhibitors available in Taiwan, vildagliptin showed the highest risk of BP (aHR, 2.849; 95% CI, 1.893\u20134.215; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001), followed by saxagliptin (aHR, 2.657; 95% CI, 1.770\u20133.934; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Subgroup analysis revealed that the higher risk of BP was observed in patients older than 65\u00a0years (aHR, 2.403; 95% CI, 1.590\u20133.627; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). This study revealed that treatment with DPP\u20104 inhibitors, especially vildagliptin, was significantly associated with an increased risk of BP among DM patients.<\/jats:p>","DOI":"10.1111\/1346-8138.15195","type":"journal-article","created":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T04:10:51Z","timestamp":1577679051000},"page":"245-250","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Increased risk of bullous pemphigoid in dipeptidyl peptidase 4 inhibitors: A nationwide, population\u2010based, cohort study in Taiwan"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-7757","authenticated-orcid":false,"given":"Chih\u2010Tsung","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Dermatology Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"},{"name":"Graduate Institute of Medical Sciences National Defense Medical 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