{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T18:58:43Z","timestamp":1768071523093,"version":"3.49.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T00:00:00Z","timestamp":1578355200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Primary cutaneous \u03b3\u03b4 T\u2010cell lymphoma (CGD\u2010TCL) is a rare form of primary cutaneous lymphoma. The histopathological features of CGD\u2010TCL are still unclear because of its rarity. Here, we report a case of a 77\u2010year\u2010old Japanese man who presented with a 9\u2010month history of erythematous plaques on his left forearm. Skin biopsy specimens revealed the infiltration of atypical medium\/large\u2010sized lymphocytes from the epidermis to the deep dermis. Atypical lymphocytes were positive for CD3, CD5, CD8 and V\u03b41, and negative for CD4, CD7, CD56, EBER\u2010ISH, intracellular antigen\u20101, granzyme B and perforin. CD30 was partially expressed. We also reviewed 246 cases of CGD\u2010TCL from the published work. CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup> double\u2010negative cases were 113 of 196 cases (57.6%), followed by CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>+<\/jats:sup> cases (52\/196, 26.5%). CD5 was expressed in 25.8% of the cases (34\/132). At least one cytotoxic molecule marker was expressed in 150 of 160 cases (93.8%). Some cases showed an indolent clinical course, especially in mycosis fungoides\u2010like CGD\u2010TCL cases. CD5 positivity and lack of cytotoxic molecule expression could be associated with a better prognosis. In addition, CD30 expression was found in approximately half of CGD\u2010TCL cases (51\/112 cases), suggesting that brentuximab vedotin could be a good treatment option for such patients. Further studies with more cases with detailed clinical and pathological information are necessary to elucidate the etiology and prognostic markers of this entity.<\/jats:p>","DOI":"10.1111\/1346-8138.15215","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T04:14:48Z","timestamp":1578456888000},"page":"300-305","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Primary cutaneous \u03b3\u03b4 T\u2010cell lymphoma with unusual immunophenotype: A case report and review of published work"],"prefix":"10.1111","volume":"47","author":[{"given":"Hiroaki","family":"Kamijo","sequence":"first","affiliation":[{"name":"Department of Dermatology University of Tokyo Graduate School of Medicine Tokyo 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