{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:24:03Z","timestamp":1791645843478,"version":"4.3.4"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Pulsed dye laser\u2010resistant port\u2010wine stains present a therapeutic challenge. The aim of this study was to evaluate the efficacy and safety of photodynamic therapy for treating these lesions. A total of 67 patients with pulsed dye laser\u2010resistant cervicofacial port\u2010wine stains were retrospectively assessed after undergoing photodynamic therapy mediated with a combination of hemoporfin and 532\u2010nm light. For objective evaluation of photodynamic therapy efficacy, first, the colorimetric changes in the port\u2010wine stain lesions were evaluated according to the\n                    <jats:italic>L<\/jats:italic>\n                    *\n                    <jats:italic>a<\/jats:italic>\n                    *\n                    <jats:italic>b<\/jats:italic>\n                    * color coordinate system, then the values of color changes (\u0394\n                    <jats:italic>E<\/jats:italic>\n                    ) and blanching rate were calculated. For subjective evaluation of improvement, photographs taken before and after photodynamic therapy were evaluated by three independent assessors blindly. Patient satisfaction was also used as a factor in the subjective evaluation. Adverse events were recorded after treatment. The median \u0394\n                    <jats:italic>E<\/jats:italic>\n                    decreased significantly from the pretreatment value of 13.42 to 9.90 at the 2\u2010month follow up (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00.001). The median blanching rate of port\u2010wine stains was 28.04% after an average of 1.21 sessions of photodynamic therapy. Based on the overall visual assessment, 46.2% patients showed excellent or good levels of improvement (&gt;50% color blanching). Adverse events were minimal, transient and self\u2010limiting. In conclusion, photodynamic therapy serves as an alternative means to treat pulsed dye laser\u2010resistant port\u2010wine stains.\n                  <\/jats:p>","DOI":"10.1111\/1346-8138.15238","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T15:00:33Z","timestamp":1580742033000},"page":"348-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":53,"title":["Retrospective study of photodynamic therapy for pulsed dye laser\u2010resistant port\u2010wine stains"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0645-0657","authenticated-orcid":false,"given":"Yue","family":"Han","sequence":"first","affiliation":[{"name":"Department of Plastic and Reconstructive Surgery Shanghai Ninth People\u2019s Hospital Shanghai Jiao Tong University School of Medicine Shanghai China"},{"name":"Department of Laser and Aesthetic Medicine Shanghai Ninth People\u2019s Hospital 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