{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T15:35:52Z","timestamp":1774366552152,"version":"3.50.1"},"reference-count":53,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tri-Service General Hospital Research Foundation","award":["TSGH-C107-004"],"award-info":[{"award-number":["TSGH-C107-004"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TSGH-C108-003"],"award-info":[{"award-number":["TSGH-C108-003"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TSGH-C108-151"],"award-info":[{"award-number":["TSGH-C108-151"]}]},{"name":"Tri-Service General Hospital Research Foundation","award":["TSGHB-109010"],"award-info":[{"award-number":["TSGHB-109010"]}]},{"name":"Medical Affairs Bureau, Ministry of Defense of Taiwan","award":["MAB-107-084"],"award-info":[{"award-number":["MAB-107-084"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Genital warts are a common sexually transmitted disease caused by human papillomavirus (HPV) infections. The prevalence of dementia is 4\u20138% in those aged 65\u00a0years or older in Taiwanese community studies, with a high social and economic burden for patients, family caregivers, the community and society. Previous studies have shown that viral infections such as herpes simplex and herpes zoster were associated with dementia. This study aimed to investigate the association between dementia and HPV infections. A population\u2010based cohort study using data from Taiwan\u2019s National Health Insurance Research Database was conducted. Fine and Grays\u2019s survival analysis was employed to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the association between genital warts and dementia. From all of the potential participants aged 50\u00a0years or more, a total of 16\u00a0116 patients were enrolled, including 4029 genital warts\u2010infected patients, with 12\u00a0087 sex\u2010, age\u2010 and indexed date\u2010matched controls (1:3). The cumulative incidences of dementia were 10.72 per 10<jats:sup>3<\/jats:sup>\u00a0person\u2010years and 6.43 per 10<jats:sup>3<\/jats:sup>\u00a0person\u2010years in the genital warts and control group, respectively. There were 475 dementia cases from the genital warts cohort during the follow\u2010up period of 15\u00a0years. The adjusted HR for dementia was 1.485 (95% CI, 1.321\u20131.668;<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) for genital warts patients after adjusting for all of the covariates. Our study indicates that genital warts infection may increase the risk of dementia.<\/jats:p>","DOI":"10.1111\/1346-8138.15277","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T05:54:04Z","timestamp":1584597244000},"page":"503-511","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Increased risk of dementia in patients with genital warts: A nationwide cohort study in Taiwan"],"prefix":"10.1111","volume":"47","author":[{"given":"Chia\u2010Hua","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dermatology Tri\u2010Service General Hospital, School of Medicine National Defense Medical Center Taipei Taiwan"},{"name":"Department of Dermatology Tri\u2010Service General Hospital, Penghu Branch National Defense Medical Center Penghu 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