{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:29:39Z","timestamp":1790504979670,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,2]],"date-time":"2020-03-02T00:00:00Z","timestamp":1583107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tri-Service Hospital Research Foundation","award":["TSGH-B109-010"],"award-info":[{"award-number":["TSGH-B109-010"]}]},{"name":"Tri-Service Hospital Research Foundation","award":["TSGH-C108-003"],"award-info":[{"award-number":["TSGH-C108-003"]}]},{"name":"Tri-Service Hospital Research Foundation","award":["TSGH-C108-036"],"award-info":[{"award-number":["TSGH-C108-036"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is an autoimmune skin disease that has a major impact on the quality of life of patients. However, a nationwide study of the association between vitiligo and the incidence of inclusive psychiatric diseases has not been conducted in the Asian population. Therefore, this study aimed to analyze the association between vitiligo and the risk of psychiatric disorders using a nationwide database in Taiwan. Data were collected from the National Health Insurance Research Database of Taiwan from 2000 to 2013. In total, 1432 subjects with vitiligo and 5728 age\u2010, sex\u2010 and index year\u2010matched controls were enrolled in this study. Patients with vitiligo tend to have more coexisting psychiatric disorders than healthy individuals, regardless of their sex, age group and facility level of care. After adjusting for sex, age, comorbidity, urbanization and facility level of care, the adjusted hazard ratio of overall psychiatric disorders for patients with vitiligo was 2.926 (95% confidence interval [CI], 2.646\u20133.236; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Among them, the highest adjusted hazard ratios were found for obsessive\u2013compulsive disorder, at 10.790 (95% CI, 9.756\u201311.932; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001). Vitiligo is associated with an increased risk of various psychiatric disorders. By providing a better understanding of the psychosocial burden associated with vitiligo, these results emphasize the need to evaluate the mental health of patients with vitiligo by treating physicians.<\/jats:p>","DOI":"10.1111\/1346-8138.15290","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T07:24:15Z","timestamp":1583220255000},"page":"470-475","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Increased risk of psychiatric disorders in adult patients with vitiligo: A nationwide, population\u2010based cohort study in Taiwan"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3317-5443","authenticated-orcid":false,"given":"Chih\u2010Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Dermatology Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ming","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"},{"name":"Graduate Institute of Medical Sciences National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Hsiang","family":"Chung","sequence":"additional","affiliation":[{"name":"School of Public Health National Defense Medical Center Taipei Taiwan"},{"name":"Taiwanese Injury Prevention and Safety Promotion Association Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Huei","family":"Tsao","sequence":"additional","affiliation":[{"name":"Department of Medical Research Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"},{"name":"Department of Microbiology and Immunology National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu\u2010Chien","family":"Chien","sequence":"additional","affiliation":[{"name":"School of Public Health National Defense Medical Center Taipei Taiwan"},{"name":"Department of Medical Research Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"},{"name":"Graduate Institute of Life Sciences National Defense Medical Center Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7138-7757","authenticated-orcid":false,"given":"Chih\u2010Tsung","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Dermatology Tri\u2010Service General Hospital National Defense Medical Center Taipei Taiwan"},{"name":"Graduate Institute of Medical Sciences National Defense Medical Center Taipei 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