{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T02:04:08Z","timestamp":1773453848200,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,15]],"date-time":"2020-03-15T00:00:00Z","timestamp":1584230400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Botryomycosis is a rare chronic suppurative granulomatous infection caused by several genera of non\u2010filamentous bacteria. The clinical and histopathological findings are similar to those of mycetoma caused by true fungi or aerobic actinomycetes. Botryomycosis is divided into cutaneous and visceral disease, with the cutaneous form being more common. Histopathology shows granules of etiologic bacteria called \u201csulfur granules\u201d. Botryomycosis occurs more commonly among immunocompromised patients, although some cases have also been reported in immunocompetent patients. We report the case of an 8\u2010year\u2010old immunocompetent boy who visited our hospital with a 4\u2010mm diameter subcutaneous tumor with mild tenderness on his right heel for several months. We surgically removed the tumor with an initial diagnosis of epidermal cyst. Histopathology showed sulfur granules surrounded by an eosinophilic matrix, indicating the Splendore\u2013Hoeppli phenomenon. The granules consisted of Gram\u2010positive cocci, leading to a diagnosis of botryomycosis. The patient was successfully treated by excision and oral trimethoprim\/sulfamethoxazole (240\u00a0mg b.i.d.) for 2\u00a0weeks as adjuvant therapy. No recurrence was noted following treatment. The subcutaneous tumor in this case was smaller than the typical in botryomycosis infections. We reviewed the infection duration and tumor size in reported cases of botryomycosis in immunocompetent patients. Small tumor size may suggest that the case is in an early stage; therefore, it is important to remove and investigate these lesions proactively.<\/jats:p>","DOI":"10.1111\/1346-8138.15308","type":"journal-article","created":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T06:32:45Z","timestamp":1584340365000},"page":"542-545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Case of cutaneous botryomycosis in an 8\u2010year\u2010old immunocompetent boy with a review of the published work"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-3442","authenticated-orcid":false,"given":"Haruna","family":"Shimagaki","sequence":"first","affiliation":[{"name":"Division of Dermatology Niigata University Graduate School of Medical and Dental Sciences Niigata 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