{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:17:50Z","timestamp":1782782270360,"version":"3.54.5"},"reference-count":72,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602784"],"award-info":[{"award-number":["81602784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703149"],"award-info":[{"award-number":["81703149"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874251"],"award-info":[{"award-number":["81874251"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rosacea is a chronic facial skin disease involved in neurovascular dysregulation and neurogenic inflammation. Behavioral factors such as stress, anxiety, depression and sleep were identified to be associated with other inflammatory skin diseases. Few studies have reported sleep status in rosacea. Aiming to investigate the relationship between rosacea and sleep, a case\u2013control survey was conducted, enrolling 608 rosacea patients and 608 sex\u2010 and age\u2010matched healthy controls. Sleep quality was assessed through the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Diagnosis and severity grading of rosacea were evaluated under the standard guidelines of the National Rosacea Society. More rosacea patients (52.3%, <jats:italic>n<\/jats:italic>\u00a0=\u00a0318) suffered poor sleep quality (PSQI, &gt;5) than the healthy controls (24.0%, <jats:italic>n<\/jats:italic>\u00a0=\u00a0146), displaying a much higher PSQI score (rosacea vs control, 6.20 vs 3.95). There was a strong association between sleep quality and rosacea (odds ratio [OR], 3.525; 95% confidence interval [CI], 2.759\u20134.519). Moreover, the severity of rosacea was also associated with sleep quality (OR, 1.847; 95% CI, 1.332\u20132.570). Single nucleotide polymorphisms in hydroxytryptamine receptor 2A and adrenoceptor\u2010\u03b21 genes, which are associated with sleep behaviour, were detected and revealed to be associated with rosacea. Furthermore, the LL\u201037\u2010induced rosacea\u2010like phenotype and sleep\u2010deprivation mice models were applied, revealing that sleep deprivation aggravated the rosacea\u2010like phenotype in mice, with higher expression of matrix metallopeptidase 9, Toll\u2010like receptor 2, cathelicidin antimicrobial peptide and vascular endothelial growth factor. In conclusion, rosacea patients presented poorer\u00a0sleep quality, as well as a higher propability of\u00a0genetic background with sleep disturbance. In addition, poor sleep might aggravate rosacea\u00a0through regulating inflammatory factors, contributing to a vicious cycle in the progression of disease.<\/jats:p>","DOI":"10.1111\/1346-8138.15339","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T03:50:24Z","timestamp":1586922624000},"page":"592-600","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Relationship between rosacea and sleep"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0973-7159","authenticated-orcid":false,"given":"Zhiqiang","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfu","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province Central South University Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihuan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyan","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faming","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology Xiangya Hospital Central South University Changsha China"},{"name":"Key Laboratory of Organ Injury, Aging and Regenerative Medicine of Hunan Province Central South University Changsha China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University Changsha China"},{"name":"Center for Molecular Medicine Xiangya Hospital Central South University Changsha China"},{"name":"Department of Dermatology The Second Affiliated Hospital of Xinjiang Medical University Urumqi China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2014.08.028"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.3527"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.326.11236"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2017.08.037"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0807-904"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13143"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17091562"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0781.2006.00220.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2015.53"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2008.00753.x"},{"key":"e_1_2_7_12_1","first-page":"26","article-title":"Rosacea, reactive oxygen species, and azelaic Acid","volume":"2","author":"Jones DA","year":"2009","journal-title":"J Clin Aesthetic Dermatol"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2010.351"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2230"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.14771"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000444082"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2012-1092"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12582"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2016"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2015.11.013"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-016-1356-1"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2009.12.001"},{"key":"e_1_2_7_23_1","first-page":"398","article-title":"Prevalence of mood and sleep problems in chronic skin diseases: a pilot study","volume":"81","author":"Mostaghimi L","year":"2008","journal-title":"Cutis"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.161330"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-017-1765-9"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120625"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2004.01.048"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(89)90047-4"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-005-4346-x"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192487"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2018.12.045"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.222"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2015.12.007"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15051034"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.40.1.74"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2012.93"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.7"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30014-1"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1616"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06457"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2012.00079"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2013.04.045"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16702"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2016.28.3.321"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12549"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17071184"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.5152\/eurasianjmed.2017.17132"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15469"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.5114\/reum.2018.79501"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-3065"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2013.06.010"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/jidsymp.2011.9"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489092"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.3109\/09273948.2013.795229"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-005-0212-3"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.105"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2010.03825.x"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.04.006"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0014-10.2010"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2014.10.023"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1097\/MAJ.0b013e31829bc950"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1911"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1808-86942011000300013"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2015.558"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325-015-1176-0"},{"key":"e_1_2_7_66_1","first-page":"114","article-title":"Effects of selected beta\u2010adrenergic blocking agents on sleep stages in spontaneously hypertensive rats","volume":"257","author":"Ongini E","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/458410"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90513-4"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.9.586"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2006.09.008"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2967"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13367"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089656"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.15339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15339","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15339","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15339","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:54:09Z","timestamp":1693972449000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,14]]},"references-count":72,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/1346-8138.15339"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15339","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,14]]},"assertion":[{"value":"2019-11-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}