{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:19:19Z","timestamp":1747181959119,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T00:00:00Z","timestamp":1586822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>New indications are being reported for intradermal botulinum toxin type A (BTX\u2010A) owing to its anti\u2010inflammatory and antipruritic actions. Its successful use for dyshidrotic hand eczema and lichen simplex has been reported in a few cases, while its utility in dry palmar eczema not associated with hyperhidrosis has not yet been investigated. The aim of this study was the assessment of the additive efficacy and tolerability of BTX\u2010A in chronic dry palmar eczema. This prospective non\u2010randomized side\u2010by\u2010side comparative study included 30 cases of chronic bilateral dry palmar eczema with no associated hyperhidrosis. Combined emollients and topical mid\u2010potency steroid on one side were compared with an additive 100\u00a0units of intradermal BTX\u2010A on the other side for efficacy and tolerability using both patient\u2010 and physician\u2010oriented scores over a period of 6\u00a0months. Timing and extent of improvement and relapse were recorded on both sides, together with the frequency of development of side\u2010effects. Both lines were effective and well tolerated, with significantly greater reduction of symptom and sign scores and higher overall patient satisfaction on the side receiving BTX\u2010A, an effect which lasted for a significantly longer duration on this side (4\u00a0months) as compared with the other side (1\u00a0month).\u00a0In conclusion,\u00a0intradermal BTX\u2010A at a dose of 100\u00a0units\/palm is beneficial and well tolerated in chronic dry palmar eczema. Compared with topical steroid and emollients alone, its addition yielded superior efficacy that was longer lasting and more satisfactory to the patients, while exerting a steroid\u2010sparing effect.<\/jats:p>","DOI":"10.1111\/1346-8138.15344","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T03:49:32Z","timestamp":1586922572000},"page":"601-608","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Botulinum toxin type A in chronic non\u2010dyshidrotic palmar eczema: A side\u2010by\u2010side comparative study"],"prefix":"10.1111","volume":"47","author":[{"given":"Aisha","family":"Ismail","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samar","family":"El\u2010Kholy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-0227","authenticated-orcid":false,"given":"Carmen","family":"Farid","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Alexandria University Alexandria Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1515\/jvetres-2017-0038"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12828"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/asj\/sjx005"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins7072435"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2009.09305.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452341"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.12510_1"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0536.2011.01915.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.06305.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1265"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sder.2011.04.008"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2011.04128.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2003.00119.x"},{"issue":"5","key":"e_1_2_6_15_1","first-page":"18","article-title":"Palmar and plantar hyperhidrosis: best practice recommendations and special considerations","volume":"79","author":"Glaser DA","year":"2007","journal-title":"Cutis"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105156"},{"volume-title":"A simple guide to IBM SPSS statistics for version 20.0. 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