{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T21:39:13Z","timestamp":1769722753842,"version":"3.49.0"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Cancer Center Research and Development Fund","award":["29-A-3"],"award-info":[{"award-number":["29-A-3"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitiligo is an autoimmune disorder resulting from the destruction of melanocytes. Several reports indicate the association between vitiligo and treatment response in advanced melanoma during immunotherapy. It has not been investigated, however, if an increase of vitiligo while on treatment with anti\u2010programmed death 1 (PD\u20101) antibodies is associated with more durable responses. The aim of this study is to evaluate the correlation between the vitiligo dynamics and clinical efficacy of anti\u2010PD\u20101 antibodies. This study included advanced melanoma patients who were treated with nivolumab or pembrolizumab and developed vitiligo thereafter. Correlation between vitiligo expansion (defined as an increase of lesion size at two separate time points at least 4\u00a0weeks apart) as well as vitiligo extent (body surface area [BSA] affected) and clinical efficacy based on response rate, progression\u2010free survival and overall survival was assessed. We retrospectively reviewed 29 patients. The median time from the initiation of anti\u2010PD\u20101 antibody to vitiligo onset was 4.3\u00a0months in patients who showed a response and 5.5\u00a0months in patients who showed no response (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.31). Twelve patients showed vitiligo expansion, and in nine of these patients, vitiligo increased to grade 2 (covering \u2265 10% BSA). Vitiligo expansion and grade 2 vitiligo showed no improvement in treatment response (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.59 and 0.25) but were associated with prolonged progression\u2010free survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.019 and 0.04). Grade 2 vitiligo also showed a trend for prolonged overall survival (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07). Trend of expansion and larger vitiligo extent may be predictive factors of prolonged survival during anti\u2010PD\u20101 antibody in melanoma patients.<\/jats:p>","DOI":"10.1111\/1346-8138.15345","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T10:45:36Z","timestamp":1586515536000},"page":"629-635","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Vitiligo expansion and extent correlate with durable response in anti\u2010programmed death 1 antibody treatment for advanced melanoma: A multi\u2010institutional retrospective study"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6972-9559","authenticated-orcid":false,"given":"Taisuke","family":"Matsuya","sequence":"first","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center Hidaka Japan"},{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3664-5818","authenticated-orcid":false,"given":"Yasuhiro","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-5341","authenticated-orcid":false,"given":"Shigeto","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Department of Dermato-Oncology\/Dermatology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7887-8126","authenticated-orcid":false,"given":"Ryota","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Teramoto","sequence":"additional","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuri","family":"Asami","sequence":"additional","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6656-8905","authenticated-orcid":false,"given":"Jiro","family":"Uehara","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Aoki","sequence":"additional","affiliation":[{"name":"Department of Dermato-Oncology\/Dermatology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1614-591X","authenticated-orcid":false,"given":"Kentaro","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Department of Dermato-Oncology\/Dermatology National Hospital Organization Kagoshima Medical Center Kagoshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0166-2658","authenticated-orcid":false,"given":"Yoshiyuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-8496","authenticated-orcid":false,"given":"Yasuhiro","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8279-9239","authenticated-orcid":false,"given":"Elisabeth","family":"Livingstone","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3680-3521","authenticated-orcid":false,"given":"Lisa","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3524-7858","authenticated-orcid":false,"given":"Dirk","family":"Schadendorf","sequence":"additional","affiliation":[{"name":"Skin Cancer Unit Department of Dermatology University Hospital Essen Essen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kagamu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Saitama Medical University International Medical Center Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3062-4872","authenticated-orcid":false,"given":"Manabu","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine University of Tsukuba Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1566-5331","authenticated-orcid":false,"given":"Masaru","family":"Honma","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3104-102X","authenticated-orcid":false,"given":"Akemi","family":"Ishida\u2010Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Dermatology Asahikawa Medical University Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4846-2418","authenticated-orcid":false,"given":"Ryuichiro","family":"Araki","sequence":"additional","affiliation":[{"name":"Community Health Science Center Saitama Medical University Iruma\u2010Gun Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0560-9969","authenticated-orcid":false,"given":"Akifumi","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Skin Oncology\/Dermatology Saitama Medical University International Medical Center Hidaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2011.02.004"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdp325"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa053007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1533209100"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000247693"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.32"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700545"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.01.6816"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.cji.0000171314.00924.2b"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.57.4756"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1136"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.13520"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.2707"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12677"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2017.1679"},{"key":"e_1_2_7_17_1","unstructured":"National Cancer Institute Division of Cancer Treatment & Diagnaosis Common Terminology Criteria for Adverse Events (CTCAE) v4.0.3. Available from URL:https:\/\/ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/ctc.htm#ctc_40"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2008.10.026"},{"issue":"60","key":"e_1_2_7_19_1","first-page":"12","article-title":"Characterisation and management of dermatologic adverse events to agents targeting the PD\u20101 receptor","volume":"2016","author":"Belum VR","year":"1990","journal-title":"Eur J Cancer"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2015.1916"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1078155216667636"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.323"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-008-0506-5"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2005.00244.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002371-199601000-00009"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29297"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.19.9919"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/pcmr.12667"}],"container-title":["The Journal of Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2F1346-8138.15345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15345","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/1346-8138.15345","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/1346-8138.15345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T03:54:19Z","timestamp":1693972459000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/1346-8138.15345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,10]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/1346-8138.15345"],"URL":"https:\/\/doi.org\/10.1111\/1346-8138.15345","archive":["Portico"],"relation":{},"ISSN":["0385-2407","1346-8138"],"issn-type":[{"value":"0385-2407","type":"print"},{"value":"1346-8138","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,10]]},"assertion":[{"value":"2019-09-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}