{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:19:19Z","timestamp":1747181959409,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T00:00:00Z","timestamp":1586908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["19cm0106434h0002"],"award-info":[{"award-number":["19cm0106434h0002"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Various serious adverse events (AE) have been reported to occur at a high rate in patients treated with BRAF plus mitogen\u2010activated protein kinase kinase (MEK) inhibitor combination therapy, but their subtypes differ among the BRAF\/MEK inhibitors. Pyrexia or a spike of fever are well\u2010known AE of BRAF inhibitors, with or without MEK inhibitors, and have been reported to have a high incidence after dabrafenib\/trametinib, but not after encorafenib\/binimetinib. In this report, we describe three cases of severe pyrexia in nivolumab\u2010resistant advanced melanoma after successful combined therapy with encorafenib plus binimetinib. Interestingly, in all cases, the serum levels of soluble CD163 C\u2010X\u2010C motif chemokine (CXCL)9, CXCL10 and CXCL11, which are known biomarkers for adult\u2010onset Still\u2019s disease (AOSD), increased in parallel with the development of pyrexia. Our present cases suggest that pyrexia caused by BRAF\/MEK inhibitors may possess a similar pathophysiology as that of AOSD.<\/jats:p>","DOI":"10.1111\/1346-8138.15346","type":"journal-article","created":{"date-parts":[[2020,4,15]],"date-time":"2020-04-15T09:19:19Z","timestamp":1586942359000},"page":"654-657","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Severe pyrexia from nivolumab\u2010resistant advanced melanoma after successful combined therapy with encorafenib plus binimetinib"],"prefix":"10.1111","volume":"47","author":[{"given":"Ryo","family":"Amagai","sequence":"first","affiliation":[{"name":"Department of Dermatology Tohoku University Graduate School of Medicine Sendai Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6809-5833","authenticated-orcid":false,"given":"Taku","family":"Fujimura","sequence":"additional","affiliation":[{"name":"Department of 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