{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T10:04:13Z","timestamp":1771063453980,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T00:00:00Z","timestamp":1588809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The Journal of Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In Japan, pyrethroid\u2010resistant head lice have been increasing; however, only 0.4% phenothrin, a pyrethroid drug, is available as an over the counter formulation. In recent years, Sumithrin<jats:sup>\u00ae<\/jats:sup> Lotion containing 5% phenothrin (PHT) was approved for scabies. In the USA, Sklice<jats:sup>\u00ae<\/jats:sup> Lotion containing 0.5% ivermectin (IVM) is used for the treatment of pyrethroid\u2010resistant head lice. Therefore, to enhance the treatment of head lice in Japan, we conducted a clinical study to confirm the efficacy and safety of a combination regimen of PHT and IVM (PI regimen). Twelve cases were enrolled and PHT was applied to all patients on day 1. On day 8, five patients (41.7%) were lice free, and PHT was applied again. Notably, seven patients were not lice free and were switched to IVM. The rate of patients who were lice free on the PI regimen, which was the primary end\u2010point, was 75.0% on day 15 and 91.7% on day 22. No adverse events were reported. A genetic analysis of the head lice collected at each visit revealed a <jats:italic>kdr<\/jats:italic> mutation in all patients. These results suggest that the PI regimen is safe and effective for the treatment of pyrethroid\u2010resistant head lice in Japan.<\/jats:p>","DOI":"10.1111\/1346-8138.15348","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T03:39:14Z","timestamp":1588909154000},"page":"720-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Efficacy and safety of a combination regimen of phenothrin and ivermectin lotion in patients with head lice in Okinawa, Japan"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9604-3667","authenticated-orcid":false,"given":"Masayo","family":"Komoda","sequence":"first","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Chiba Japan"},{"name":"Translational Research Center Research Institute for Science and Technology Tokyo University of Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-444X","authenticated-orcid":false,"given":"Sayaka","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of the Ryukyus Graduate School of Medicine Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenzo","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of the Ryukyus Graduate School of Medicine Okinawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Yanase","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Materials Science and Technology Faculty of Industrial Science and Technology Tokyo University of Science Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Miyajima","sequence":"additional","affiliation":[{"name":"Department of Biopharmaceutics Meiji Pharmaceutical University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Yoshimasu","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eiji","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Ozeki","sequence":"additional","affiliation":[{"name":"Department of Medical Safety Faculty of Pharmaceutical Sciences Tokyo University of Science Chiba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norihisa","family":"Ishii","sequence":"additional","affiliation":[{"name":"National Sanatorium Tamazenshoen Higashimurayama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,7]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1355","article-title":"Head lice","volume":"14","author":"Burgess IF","year":"2015","journal-title":"BMJ Clin Evid"},{"key":"e_1_2_7_3_1","unstructured":"TOSHIMA City of Arts & Culture [homepage on the internet].Tokyo: Head Lice Support Manual New version byToshima\u2010ku Ikebukuro Public Health Center; [Cited 2020 Feb 15]. Available from URL:http:\/\/www.city.toshima.lg.jp\/214\/kurashi\/ese\/nezumitomushi\/gaichu\/shirami.html."},{"key":"e_1_2_7_4_1","unstructured":"Centers for Disease Control and Prevention Web site[homepage on the internet].Head lice.Atlanta:U.S. Department of Health & Human Services; [Cited 2020 Feb 15]. Available from URL:https:\/\/www.cdc.gov\/parasites\/lice\/head\/treatment.html."},{"key":"e_1_2_7_5_1","first-page":"392","article-title":"Clinical report\u2010head lice","volume":"126","author":"Frankowski BL","year":"2010","journal-title":"Am Acad Pediatr"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/45.5.912"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjw023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/pde.12982"},{"key":"e_1_2_7_9_1","unstructured":"U.S. Food and Drug Administration[Drugs@FDA on the internet].USA: Drug Approval Package of Sklice (ivermectin) Lotion 0.5%; [Cited 2020 Feb 15]. Available from URL:https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2012\/202736_sklice_toc.cfm."},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-017-5461-7"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/pch\/pxx165"},{"issue":"70","key":"e_1_2_7_12_1","first-page":"2","article-title":"Safety and efficacy of a 100 % dimethicone pediculocide in school\u2010age children","volume":"15","author":"Ihde ES","year":"2015","journal-title":"BMC Pediatr"},{"issue":"8","key":"e_1_2_7_13_1","first-page":"1","article-title":"Do drowning and anoxia kill head lice?","volume":"25","author":"Candy K","year":"2018","journal-title":"Parasite"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jmedent\/42.5.826"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jme\/tjx045"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1603\/033.046.0110"},{"key":"e_1_2_7_17_1","first-page":"2898","article-title":"Development of pyrethroid drug resistance in head lice development and effective control measures","volume":"121","author":"Tomita T","year":"2011","journal-title":"Jpn J Dermatol"},{"key":"e_1_2_7_18_1","unstructured":"Pharmaceuticals and Medical Devices Agency[homepage on the internet].Tokyo: package insert of SUMITHRIN\u00aeShampoo\u2010type; [Cited 2020 Jan 6]. 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